ArticlePloS one2012
Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A Statistical Mechanics Approach to Describe Cell Reorientation Under Stretch.Bulletin of mathematical biology · 2023Article
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- The effect of cyclic stretch on aortic viscoelasticity and the putative role of smooth muscle focal adhesion.Frontiers in physiology · 2023Article
- Cellular mechanics of wound formation in single cell layer under cyclic stretching.Biophysical journal · 2022Article
- Making waves: A proposed new role for myosin-binding protein C in regulating oscillatory contractions in vertebrate striated muscle.The Journal of general physiology · 2021Article
- Uniaxial Cyclic Stretching Promotes Chromatin Accessibility of Gene Loci Associated With Mesenchymal Stem Cells Morphogenesis and Osteogenesis.Frontiers in cell and developmental biology · 2021Article
- Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.Journal of cell science · 2020Review
- Good advice for endothelial cells: Get in line, relax tension, and go with the flow.APL bioengineering · 2020Article
- Mechanical Model for Catch-Bond-Mediated Cell Adhesion in Shear Flow.International journal of molecular sciences · 2020Article
- Orientations of Cells on Compliant Substrates under Biaxial Stretches: A Theoretical Study.Biophysical journal · 2018Article
- Mechanical and Systems Biology of Cancer.Computational and structural biotechnology journal · 2018Review
- A general model of focal adhesion orientation dynamics in response to static and cyclic stretch.Communications biology · 2018Article
- Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology.Nature communications · 2017Article
- Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.Physics of life reviews · 2017Review
- Intermediate filament reorganization dynamically influences cancer cell alignment and migration.Scientific reports · 2017Article
- A Tensegrity Model of Cell Reorientation on Cyclically Stretched Substrates.Biophysical journal · 2016Article
- The effects of mechanical stimulation on controlling and maintaining marrow stromal cell differentiation into vascular smooth muscle cells.Journal of biomechanical engineering · 2015Article
- Probing time-dependent mechanical behaviors of catch bonds based on two-state models.Scientific reports · 2015Article
- A biomechanical model for fluidization of cells under dynamic strain.Biophysical journal · 2015Article
- Contractile fibers and catch-bond clusters: a biological force sensor?Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied uniaxial cyclic stretch. The model indicates that the catch bonds in the focal adhesions experience a periodically oscillating internal force with amplitude and frequency controlled by two intrinsic clocks of the stress fiber, one associated with localized activation and the other with homogeneous activation of sarcomere units along the stress fiber. It is shown that this oscillating force due to cyclic stretch tends to destabilize focal adhesions by reducing the lifetime of catch bonds. The resulting slide or relocation of focal adhesions then causes the associated stress fiber to shorten and rotate to configurations nearly perpendicular to the stretching direction. These predicted behaviors from our model are consistent with a wide range of experimental observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.