ArticlePLoS biology2012
Recombination modulates how selection affects linked sites in Drosophila.
Article in PLoS biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 118 citations in OpenAlex.
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- Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data.Molecular ecology · 2025Review
- A high-resolution crossover landscape in Drosophila santomea reveals rapid and concerted evolution of multiple properties of crossing over control.PLoS genetics · 2025Article
- The recombination landscape of introgression in yeast.PLoS genetics · 2025Article
- The recombination landscape of introgression in yeast.bioRxiv : the preprint server for biology · 2024Article
- The role of recombination dynamics in shaping signatures of direct and indirect selection across theProceedings. Biological sciences · 2024Article
- The roles of balancing selection and recombination in the evolution of rattlesnake venom.Nature ecology & evolution · 2022Article
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- Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba.PLoS genetics · 2022Article
- Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut.PLoS genetics · 2022Article
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- Large genetic diversity and strong positive selection in F-box and GPCR genes among the wild isolates of Caenorhabditis elegans.Genome biology and evolution · 2021Article
- Background Selection Does Not Mimic the Patterns of Genetic Diversity Produced by Selective Sweeps.Genetics · 2020Article
- Extensive Recombination Suppression and Epistatic Selection Causes Chromosome-Wide Differentiation of a Selfish Sex Chromosome inGenetics · 2020Article
- From molecules to populations: appreciating and estimating recombination rate variation.Nature reviews. Genetics · 2020Review
- The Intracellular SymbiontInsects · 2020Article
- Effects of marker type and filtering criteria onRoyal Society open science · 2019Article
- Mutational Landscape of Spontaneous Base Substitutions and Small Indels in ExperimentalGenetics · 2019Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
One of the most influential observations in molecular evolution has been a strong association between local recombination rate and nucleotide polymorphisms across the genome. This is interpreted as evidence for ubiquitous natural selection. The alternative explanation, that recombination is mutagenic, has been rejected by the absence of a similar association between local recombination rate and nucleotide divergence between species. However, many recent studies show that recombination rates are often very different even in closely related species, questioning whether an association between recombination rate and divergence between species has been tested satisfactorily. To circumvent this problem, we directly surveyed recombination across approximately 43% of the D. pseudoobscura physical genome in two separate recombination maps and 31% of the D. miranda physical genome, and we identified both global and local differences in recombination rate between these two closely related species. Using only regions with conserved recombination rates between and within species and accounting for multiple covariates, our data support the conclusion that recombination is positively related to diversity because recombination modulates Hill-Robertson effects in the genome and not because recombination is predominately mutagenic. Finally, we find evidence for dips in diversity around nonsynonymous substitutions. We infer that at least some of this reduction in diversity resulted from selective sweeps and examine these dips in the context of recombination rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.