ArticleOncoTargets and therapy2012
Extramedullary plasmacytoma in the presence of multiple myeloma: clinical correlates and prognostic relevance.
Article in OncoTargets and therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Analysis of clinical features, treatment response, and prognosis among 61 elderly newly diagnosed multiple myeloma patients: a single-center report.World journal of surgical oncology · 2015Trial
- Clinical features and treatment outcome in newly diagnosed Chinese patients with multiple myeloma: results of a multicenter analysis.Blood cancer journal · 2014Trial
- Unmasking multiple myeloma first presentation as pericardial effusion with tamponade physiology: a case report.Journal of medical case reports · 2026Article
- Article
- Efficacy and Safety Analysis of VRD-PDCE in Treatment-Native Patients with Multiple Extramedullary Plasmacytomas or Plasma Cell Leukemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023Article
- IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection.Leukemia research reports · 2023Article
- Myelomatous ascites and pleural effusion in relapsed multiple myeloma.Clinical case reports · 2022Article
- Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis.Oncoimmunology · 2022Article
- Refractory multiple myeloma with extramedullary plasmacytoma of the spleen and suspicious teratoma: a rare case report and literature review.International journal of clinical and experimental pathology · 2021Article
- Article
- Article
- Modeling Covariate-Adjusted Survival for Economic Evaluations in Oncology.PharmacoEconomics · 2019Article
- Clinical analysis of 40 multiple myeloma patients with extramedullary plasmacytoma of the head.The Journal of international medical research · 2016Article
- Solitary extraosseous plasmacytoma.Clinical case reports · 2016Article
- A Case of Posterior Mediastinal Plasmacytoma Confounded by Community-Acquired Pneumonia.Tuberculosis and respiratory diseases · 2015Article
- [Clinical analysis of multiple myeloma patients with bone-related extramedullary disease: a longitudinal study on 834 consecutive patients in a single center of China].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- Clinical characteristics of a group of patients with multiple myeloma who had two different λ light chains by immunofixation electrophoresis: A retrospective study from a single center.Experimental and therapeutic medicine · 2015Article
- Recurrent extramedullary plasmacytoma in asymptomatic multiple myeloma: a case report.Journal of medical case reports · 2015Article
- Retrospective matched-pairs analysis of bortezomib plus dexamethasone versus bortezomib monotherapy in relapsed multiple myeloma.Haematologica · 2015Article
- Endoscopic ultrasound-guided fine needle aspiration and diagnosis of omental plasmacytoma.Endoscopic ultrasoundArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe studied the clinical and laboratory features and outcomes of multiple myeloma (MM) with extramedullary plasmocytoma (EP) disease both at diagnosis and during the course of MM. PATIENTS AND
methodsForty-two patients of 467 patients with MM were retrospectively analyzed from both the 100th Hospital of the People's Liberation Army and Shanghai Changzheng Hospitals. The clinical characteristics, laboratory parameters, responses, risk factors, and outcomes were analyzed.
resultsThe median age was 53 years with a male/female sex ratio of 34:8. Twenty-six patients had EP disease at the time of diagnosis, and 16 patients developed EP during the course of the disease. We found that the Durie-Salmon stage, serum lactate dehydrogenase level, beta-2-microglobulin, complete blood counts, albumin, and the type of immunoglobulin (Ig) were not associated with the development of EP disease. Patients who developed EP during the course of MM had a higher ratio of plasmocytes and premature plasmocytes in the bone marrow with lower C-reactive protein level and earlier stage of International Staging System for Lung Cancer at the diagnosis of MM compared with patients who presented with EP at diagnosis. Once the patients developed EP disease, they frequently showed resistance to chemotherapy. With a median follow-up of 30 months, 19 patients were alive. Log-rank univariate analysis showed that patients with EP who had normal C-reactive protein, higher hemoglobin, lower serum lactate dehydrogenase, and stage I of International Staging System for Lung Cancer had longer survival. However, cyclooxygenase multivariate analysis failed to show statistical significance for any factor.
conclusionsEP disease is the MM end-phase and is not a rare manifestation of MM with a cumulative incidence of 9% of MM. The prognosis is very poor once the diagnosis of EP disease is concurrent with MM.
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