ArticleClinical ophthalmology (Auckland, N.Z.)2012
Transepithelial corneal collagen cross-linking in ultrathin keratoconic corneas.
Article in Clinical ophthalmology (Auckland, N.Z.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.The Cochrane database of systematic reviews · 2021Pooled it
- Epithelial-Island Corneal Crosslinking in the Treatment of Progressive Keratoconus Patients with Thin Corneas: 2-Year Visual, Refractive, Keratometric, Tomographic, and Aberrometric Outcomes.Turkish journal of ophthalmology · 2026Article
- Safety and efficacy of keratorefractive surgery in diabetes mellitus: A clinical review.World journal of clinical cases · 2026Review
- Safety and efficacy of contact lens-assisted accelerated corneal cross-linking using Nelfilcon A in thin corneas.International ophthalmology · 2026Article
- Accelerated CXL Versus Accelerated Contact-Lens Assisted CXL Treatment for Progressive Keratoconus-A 3-Year Retrospective Comparative Follow-Up.Journal of clinical medicine · 2025Article
- Sociodemographic predictors of acute corneal hydrops in patients with unstable keratoconus.PloS one · 2025Article
- Efficacy, Safety, and Outcomes following Accelerated and Iontophoresis Corneal Crosslinking in Progressive Keratoconus.Journal of clinical medicine · 2023Article
- Norepinephrine as an Enhancer Promoting Corneal Penetration of Riboflavin for Transepithelial Corneal Crosslinking.Translational vision science & technology · 2023Article
- Recent advances in medicinal compounds related to corneal crosslinking.Frontiers in pharmacology · 2023Review
- Long-term visual, refractive, tomographic and aberrometric outcomes of corneal collagen crosslinking (CXL) with or without hypoosmolar riboflavin solution in the treatment of progressive keratoconus patients with thin corneas.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Outcomes of customized topographic guided epithelial debridement for corneal collagen cross-linking.International ophthalmology · 2022Article
- Epi-off-lenticule-on corneal collagen cross-linking in thin keratoconic corneas.International ophthalmology · 2020Article
- Effect of corneal cross-linking on endothelial cell density and morphology in the peripheral cornea.BMC ophthalmology · 2020Article
- Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression.International journal of ophthalmology · 2020Article
- Current concepts in crosslinking thin corneas.Indian journal of ophthalmology · 2019Review
- Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques.International ophthalmology · 2018Article
- Current perspectives on corneal collagen crosslinking (CXL).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Review
- Updates on Managements for Keratoconus.Journal of current ophthalmology · 2018Review
- Outcomes of iontophoretic corneal collagen crosslinking in keratoconic eyes with very thin corneas.Medicine · 2017Article
- Recent advances in corneal collagen cross-linking.Indian journal of ophthalmology · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this paper was to report the results of transepithelial corneal collagen cross-linking (CXL) with modified riboflavin and ultraviolet A irradiation in patients affected by keratoconus, each with thinnest pachymetry values of less than 400 μm (with epithelium) and not treatable using standard de-epithelialization techniques.
methodsSixteen patients affected by progressive keratoconus with thinnest pachymetry values ranging from 331 μm to 389 μm underwent transepithelial CXL in one eye using a riboflavin 0.1% solution in 15% Dextran T500 containing ethylenediamine tetra-acetic acid 0.01% and trometamol to enhance epithelial penetration. The patients underwent complete ophthalmological examination, including endothelial cell density measurements and computerized videokeratography, before CXL and at one day, one week, and one, 6, and 12 months thereafter.
resultsEpithelial healing was complete in all patients after one day of use of a soft bandage contact lens. No side effects or damage to the limbal region was observed during the follow-up period. All patients showed slightly improved uncorrected and spectacle-corrected visual acuity; keratometric astigmatism showed reductions (up to 5.3 D) and apical ectasia power decreased (K(max) values reduced up to 4.3 D). Endothelial cell density was unchanged.
conclusionApplication of transepithelial CXL using riboflavin with substances added to enhance epithelial permeability was safe, seemed to be moderately effective in keratoconic eyes with ultrathin corneas, and applications of the procedure could be extended to patients with advanced keratoconus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.