ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Posthearing Ca(2+) currents and their roles in shaping the different modes of firing of spiral ganglion neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Upregulation of the CaAging cell · 2024Article
- Demyelination and NaeNeuro · 2024Article
- Recent Therapeutic Progress and Future Perspectives for the Treatment of Hearing Loss.Biomedicines · 2023Review
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- Association between CaExperimental gerontology · 2021Article
- Single-Cell RNA Analysis of Type I Spiral Ganglion Neurons Reveals aFrontiers in molecular neuroscience · 2020Article
- The local translation ofAging · 2019Article
- Early functional alterations in membrane properties and neuronal degeneration are hallmarks of progressive hearing loss in NOD mice.Scientific reports · 2019Article
- Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.Scientific reports · 2019Article
- Localizing Proton-Mediated Inhibitory Feedback at the Retinal Horizontal Cell-Cone Synapse with Genetically-Encoded pH Probes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Deletion of the CaFrontiers in cellular neuroscience · 2019Article
- Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Functions of CaBP1 and CaBP2 in the peripheral auditory system.Hearing research · 2018Article
- CaBP1 regulates CaMolecular and cellular neurosciences · 2018Article
- Age-Dependent Up-Regulation of HCN Channels in Spiral Ganglion Neurons Coincide With Hearing Loss in Mice.Frontiers in aging neuroscience · 2018Article
- Noise-Induced "Toughening" Effect in Wistar Rats: Enhanced Auditory Brainstem Responses Are Related to Calretinin and Nitric Oxide Synthase Upregulation.Frontiers in neuroanatomy · 2016Article
- Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Etiology of distinct membrane excitability in pre- and posthearing auditory neurons relies on activity of Cl- channel TMEM16A.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Unmasking of spiral ganglion neuron firing dynamics by membrane potential and neurotrophin-3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Functional significance of K+ channel β-subunit KCNE3 in auditory neurons.The Journal of biological chemistry · 2014Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Whereas prehearing spiral ganglion neurons (SGNs) rely faithfully on outputs from spontaneously active developing hair cells, the electrical phenotypes of posthearing neurons are shaped by distinct rapid and graded receptor potentials from hair cells. To date, technical difficulties in isolation of fragile posthearing neurons from the rigid bony labyrinth of the inner ear have hindered analyses of the electrical phenotype of SGNs. Therefore, we have recently developed new strategies to isolate posthearing mouse SGNs for functional analyses. Here, we describe the coarse and fine properties of Ca(2+) currents, which sculpt the firing properties of posthearing SGNs. Murine SGNs express multiple Ca(2+) channel currents to enable diverse functions. We have demonstrated that suppression of Ca(2+) currents results in significant hyperpolarization of the resting membrane potential (rmp) of basal SGNs, suggesting that Ca(2+) influx primes rmp for excitation. In contrast, removal of external Ca(2+) has modest effects on rmp of apical SGNs. The blockade of Ca(2+) currents with a mixture of specific blockers attenuates spontaneously active SGNs. Paradoxically, different subtypes of Ca(2+) currents, such as R-type currents, may activate resting outward conductances since blockage of the current results in depolarization of rmp. In keeping with whole-cell current data, single-channel records revealed multiple diverse Ca(2+) channels in SGNs. Additionally, there were differential expressions of distinct Ca(2+) current densities in the apicobasal contour of the adult cochlea. This report provides invaluable insights into Ca(2+)-dependent processes in adult SGNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.