ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Osmolarity regulates Caenorhabditis elegans egg-laying behavior via chemosensory and biophysical mechanisms.The Journal of experimental biology · 2025Article
- High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations.BMC biology · 2025Article
- Food sensing controlsScience advances · 2025Article
- A specific folate activates serotonergic neurons to control C. elegans behavior.Nature communications · 2024Article
- Dissecting the Neuronal Contributions of the Lipid Regulator NHR-49 Function in Lifespan and Behavior inLife (Basel, Switzerland) · 2023Article
- Semantic representation of neural circuit knowledge in Caenorhabditis elegans.Brain informatics · 2023Article
- A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission.Current biology : CB · 2023Article
- Muscle-directed mechanosensory feedback activates egg-laying circuit activity and behavior in Caenorhabditis elegans.Current biology : CB · 2023Article
- A single neuron inbioRxiv : the preprint server for biology · 2023Article
- Article
- Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Reduced CaFrontiers in neuroscience · 2022Article
- Article
- Neural and behavioral control inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling ineLife · 2020Article
- Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development inDevelopment (Cambridge, England) · 2019Article
- CamicroPublication biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
To identify molecular mechanisms that function in G-protein signaling, we have performed molecular genetic studies of a simple behavior of the nematode Caenorhabditis elegans, egg laying, which is driven by a pair of serotonergic neurons, the hermaphrodite-specific neurons (HSNs). The activity of the HSNs is regulated by the G(o)-coupled receptor EGL-6, which mediates inhibition of the HSNs by neuropeptides. We report here that this inhibition requires one of three inwardly rectifying K(+) channels encoded by the C. elegans genome: IRK-1. Using ChannelRhodopsin-2-mediated stimulation of HSNs, we observed roles for egl-6 and irk-1 in regulating the excitability of HSNs. Although irk-1 is required for inhibition of HSNs by EGL-6 signaling, we found that other G(o) signaling pathways that inhibit HSNs involve irk-1 little or not at all. These findings suggest that the neuropeptide receptor EGL-6 regulates the potassium channel IRK-1 via a dedicated pool of G(o) not involved in other G(o)-mediated signaling. We conclude that G-protein-coupled receptors that signal through the same G-protein in the same cell might activate distinct effectors and that specific coupling of a G-protein-coupled receptor to its effectors can be determined by factors other than its associated G-proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.