Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Oxytocin modulates social distance between males and females.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
106 citing papers in PubMed.
- Post-encoding administration of oxytocin selectively enhances memory consolidation of male faces in females.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.Scientific reports · 2023Trial
- Common and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear.Proceedings of the National Academy of Sciences of the United States of America · 2020Trial
- Oxytocin increases eye-gaze towards novel social and non-social stimuli.Social neuroscience · 2019Trial
- Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial.Psychoneuroendocrinology · 2019Trial
- Oxytocin Facilitates Approach Behavior to Positive Social Stimuli via Decreasing Anterior Insula Activity.The international journal of neuropsychopharmacology · 2018Trial
- Placebo treatment facilitates social trust and approach behavior.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- How the brain codes intimacy: The neurobiological substrates of romantic touch.Human brain mapping · 2017Trial
- Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.Brain connectivity · 2017Trial
- Oxytocin differentially modulates pavlovian cue and context fear acquisition.Social cognitive and affective neuroscience · 2017Trial
- Oxytocin enhances cognitive control of food craving in women.Human brain mapping · 2016Trial
- Oxytocin Facilitates Pavlovian Fear Learning in Males.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- The neuropeptide oxytocin modulates consumer brand relationships.Scientific reports · 2015Trial
- The influence of oxytocin on volitional and emotional ambivalence.Social cognitive and affective neuroscience · 2015Trial
- The beneficial effect of oxytocin on avoidance-related facial emotion recognition depends on early life stress experience.Psychopharmacology · 2014Trial
- Oxytocin facilitates the sensation of social stress.Human brain mapping · 2014Trial
- An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Oxytocin enhances brain reward system responses in men viewing the face of their female partner.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Oxytocin enhances social persuasion during hypnosis.PloS one · 2013Trial
- Cardiac Synchrony During Collaborative Drawing: A Longitudinal Comparison of Same Generation and Intergenerational Dyads.Annals of the New York Academy of Sciences · 2026Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, interpersonal romantic attraction and the subsequent development of monogamous pair-bonds is substantially predicted by influential impressions formed during first encounters. The prosocial neuropeptide oxytocin (OXT) has been identified as a key facilitator of both interpersonal attraction and the formation of parental attachment. However, whether OXT contributes to the maintenance of monogamous bonds after they have been formed is unclear. In this randomized placebo-controlled trial, we provide the first behavioral evidence that the intranasal administration of OXT stimulates men in a monogamous relationship, but not single ones, to keep a much greater distance (~10-15 cm) between themselves and an attractive woman during a first encounter. This avoidance of close personal proximity occurred in the physical presence of female but not male experimenters and was independent of gaze direction and whether the female experimenter or the subject was moving. We further confirmed this unexpected finding using a photograph-based approach/avoidance task that showed again that OXT only stimulated men in a monogamous relationship to approach pictures of attractive women more slowly. Importantly, these changes cannot be attributed to OXT altering the attitude of monogamous men toward attractive women or their judgments of and arousal by pictures of them. Together, our results suggest that where OXT release is stimulated during a monogamous relationship, it may additionally promote its maintenance by making men avoid signaling romantic interest to other women through close-approach behavior during social encounters. In this way, OXT may help to promote fidelity within monogamous human relationships.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.