Evidence map›Paper›PMID 23152370›Full record

ArticleThe Journal of general virology2013

Full-length genome sequences of five hepatitis C virus isolates representing subtypes 3g, 3h, 3i and 3k, and a unique genotype 3 variant.

Ling Lu, Chunhua Li, Jie Yuan, Teng Lu, Hiroaki Okamoto, Donald G Murphy

Abstract read
In one paragraph

Article in The Journal of general virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ling LuCancer Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Chunhua LiCancer Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jie YuanDepartment of Biochemistry of Sun Yat-sen University, Guangzhou 510089, PR China.
Teng LuUniversity of Southern California, Los Angeles, CA 90089, USA.
Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi-Ken 329-0498, Japan.
Donald G MurphyInstitut national de santé publique du Québec, Laboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, QC, Canada.

Funding

HCV Genotype 6: A Model for HCV Genetics and Molecular Epidemiology StudiesR01AI080734 · NIAID · UNIVERSITY OF UTAH · PI LU, LING · 2009 to 2011
$1.1M
NIAID NIH HHS R01 AI080734NIAID NIH HHS R01 AI080734-03A
6 · The paper itself

Abstract

We characterized the full-length genomes of five distinct hepatitis C virus (HCV)-3 isolates. These represent the first complete genomes for subtypes 3g and 3h, the second such genomes for 3k and 3i, and of one novel variant presently not assigned to a subtype. Each genome was determined from 18-25 overlapping fragments. They had lengths of 9579-9660 nt and each contained a single ORF encoding 3020-3025 aa. They were isolated from five patients residing in Canada; four were of Asian origin and one was of Somali origin. Phylogenetic analysis using 64 partial NS5B sequences differentiated 10 assigned subtypes, 3a-3i and 3k, and two additional lineages within genotype 3. From the data of this study, HCV-3 full-length sequences are now available for six of the assigned subtypes and one unassigned. Our findings should add insights to HCV evolutionary studies and clinical applications.

Indexed as

Genome, ViralGenotypeBase SequenceBiological EvolutionGene Expression Regulation, ViralHepacivirusHepatitis CHumansMolecular Sequence DataPhylogeny

Identifiers

PMID23152370
PMCPMC3709609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.