Evidence map›Paper›PMID 23152283›Full record

SynthesisThe Cochrane database of systematic reviews2012

Preoperative physical therapy for elective cardiac surgery patients.

Erik H J Hulzebos, Yolba Smit, Paul P J M Helders, Nico L U van Meeteren

5 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 78 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02644876 phase4completednot on this mapstarted 2015, after this paper: background citation

Preventive Effects of Penehyclidine Hydrochloride Inhalation on Postoperative Pulmonary Complications in High-risk Patients: a Randomized, Double-blind, and Placebo Controlled Study

TypeinterventionalSponsorPeking University First HospitalRan2015 to 2018Enrolled864ConditionsPostoperative ComplicationsArmsPenehyclidine inhalation, Placebo inhalation
NCT03113565 completednot on this mapstarted 2017, after this paper: background citation

Connected Electronic Wrist Strap for Patient Follow-up After Cardiac Surgery

Typeobservational_patient_registrySponsorCMC Ambroise ParéRan2017 to 2018Enrolled137ConditionsCardiac Surgery, Surgery--Complications, Cardiac Disease, Physical DisabilityArmsCount daily number of footsteps.
NCT03568110 completednot on this mapstarted 2019, after this paper: background citation

The Impact of Frailty on the Postoperative Outcomes of Gastric Cancer Surgery

Typeobservational_patient_registrySponsorParc de Salut MarRan2019 to 2023Enrolled432ConditionsGastric Cancer, Frail Elderly Syndrome, Postoperative Complications, Quality of Life
NCT03868709 phase4completednot on this mapstarted 2019, after this paper: background citation

Impact of Prophylactic Penehyclidine Hydrochloride Inhalation on Long-term Outcome in High-risk Patients: 3-year Follow-up of a Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2019 to 2021Enrolled864ConditionsPostoperative Complications, Long-term OutcomeArmsPenehyclidine inhalation, Placebo inhalation
NCT05763238 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Pre-operative Exercise Therapy on Postoperative Outcomes in Children With Corrective Cardiac Surgeries.

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled46ConditionsQuality of Life, Congenital Heart Disease, Heart, Surgery, Heart, Functional Disturbance as ResultArmsINTERVENTION GROUP, CONTROL GROUP
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 7 syntheses or guidelines pooled it, 181 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Erik H J HulzebosDepartment of Child Development and Exercise Center,University Children’s Hospital and Medical Center Utrecht, Utrecht, Netherlands. 2c/o Cochrane Heart Group, London, UK. h.hulzebos@umcutrecht.nl
Yolba Smit
Paul P J M Helders
Nico L U van Meeteren
Cochrane · GBNetherlands Organisation for Applied Scientific Research · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAfter cardiac surgery, physical therapy is a routine procedure delivered with the aim of preventing postoperative pulmonary complications.

objectivesTo determine if preoperative physical therapy with an exercise component can prevent postoperative pulmonary complications in cardiac surgery patients, and to evaluate which type of patient benefits and which type of physical therapy is most effective. SEARCH

methodsSearches were run on the Cochrane Central Register of Controlled Trials (CENTRAL) on the Cochrane Library (2011, Issue 12 ); MEDLINE (1966 to 12 December 2011); EMBASE (1980 to week 49, 2011); the Physical Therapy Evidence Database (PEDro) (to 12 December 2011) and CINAHL (1982 to 12 December 2011). SELECTION CRITERIA: Randomised controlled trials or quasi-randomised trials comparing preoperative physical therapy with no preoperative physical therapy or sham therapy in adult patients undergoing elective cardiac surgery. DATA COLLECTION AND ANALYSIS: Data were collected on the type of study, participants, treatments used, primary outcomes (postoperative pulmonary complications grade 2 to 4: atelectasis, pneumonia, pneumothorax, mechanical ventilation > 48 hours, all-cause death, adverse events) and secondary outcomes (length of hospital stay, physical function measures, health-related quality of life, respiratory death, costs). Data were extracted by one review author and checked by a second review author. Review Manager 5.1 software was used for the analysis. MAIN

resultsEight randomised controlled trials with 856 patients were included. Three studies used a mixed intervention (including either aerobic exercises or breathing exercises); five studies used inspiratory muscle training. Only one study used sham training in the controls. Patients that received preoperative physical therapy had a reduced risk of postoperative atelectasis (four studies including 379 participants, relative risk (RR) 0.52; 95% CI 0.32 to 0.87; P = 0.01) and pneumonia (five studies including 448 participants, RR 0.45; 95% CI 0.24 to 0.83; P = 0.01) but not of pneumothorax (one study with 45 participants, RR 0.12; 95% CI 0.01 to 2.11; P = 0.15) or mechanical ventilation for > 48 hours after surgery (two studies with 306 participants, RR 0.55; 95% CI 0.03 to 9.20; P = 0.68). Postoperative death from all causes did not differ between groups (three studies with 552 participants, RR 0.66; 95% CI 0.02 to 18.48; P = 0.81). Adverse events were not detected in the three studies that reported on them. The length of postoperative hospital stay was significantly shorter in experimental patients versus controls (three studies with 347 participants, mean difference -3.21 days; 95% CI -5.73 to -0.69; P = 0.01). One study reported a reduced physical function measure on the six-minute walking test in experimental patients compared to controls. One other study reported a better health-related quality of life in experimental patients compared to controls. Postoperative death from respiratory causes did not differ between groups (one study with 276 participants, RR 0.14; 95% CI 0.01 to 2.70; P = 0.19). Cost data were not reported on. AUTHORS'

conclusionsEvidence derived from small trials suggests that preoperative physical therapy reduces postoperative pulmonary complications (atelectasis and pneumonia) and length of hospital stay in patients undergoing elective cardiac surgery. There is a lack of evidence that preoperative physical therapy reduces postoperative pneumothorax, prolonged mechanical ventilation or all-cause deaths.

Indexed as

AdultBreathing ExercisesCardiac Surgical ProceduresCause of DeathElective Surgical ProceduresExerciseExercise TherapyHumansLung DiseasesPneumoniaPneumothoraxPreoperative CarePulmonary AtelectasisRandomized Controlled Trials as Topic

Identifiers

PMID23152283
PMCPMC8101691
OpenAlexW2143294206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.