ArticleHuman brain mapping2014
Regionally specific increased volume of the amygdala in Williams syndrome: evidence from surface-based modeling.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Autism and Williams syndrome: truly mirror conditions in the socio-cognitive domain?International journal of developmental disabilities · 2022Review
- Williams Syndrome, Human Self-Domestication, and Language Evolution.Frontiers in psychology · 2019Article
- A postmortem stereological study of the amygdala in Williams syndrome.Brain structure & function · 2018Article
- Personal Space Regulation in Williams Syndrome: The Effect of Familiarity.Journal of autism and developmental disorders · 2016Article
- Neurobiology of social behavior abnormalities in autism and Williams syndrome.Nature neuroscience · 2016Review
- Sex differences in amygdala shape: Insights from Turner syndrome.Human brain mapping · 2016Article
- Oxytocin, vasopressin, and Williams syndrome: epigenetic effects on abnormal social behavior.Frontiers in genetics · 2015Article
- Altered microstructure within social-cognitive brain networks during childhood in Williams syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Typical and atypical brain development: a review of neuroimaging studies.Dialogues in clinical neuroscience · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Williams syndrome (WS) is a condition caused by a contiguous deletion of approximately 26-28 genes from chromosome 7, and is characterized by abnormal social and emotional processing and abnormal structure and function of the amygdala. Prior studies show that the amygdala is relatively enlarged in WS, but very little is known regarding the regional specificity of increased amygdalar volume in this condition. Here we investigated the regional specificity of structural alterations of the amygdala in WS, compared to a typically developing (TD) control group. We acquired high resolution brain MRI data from 79 participants (39 WS, 40 TD) and used a surface-based analytical modeling approach. The WS group exhibited several areas of increased radial expansion of the amygdalar surface and no areas of decreased radial expansion of the amygdalar surface compared to TD controls. The areas found to exhibit particularly increased radial expansion in WS included the bilateral posterior cortical nucleus, lateral nucleus, and the central nucleus. This greater regional and anatomical specificity of altered amygdala structure in WS contributes to a model relating genetic risk in WS to the development of key brain regions for social and emotional functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.