Evidence map›Paper›PMID 23151999›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine

Mechanisms of memory enhancement.

Sarah A Stern, Cristina M Alberini

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Deciphering Neuroprotective Effect ofCurrent drug targets · 2024
    Review
  6. Article
  7. Standardized extract ofLearning & memory (Cold Spring Harbor, N.Y.) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Plexin-A1 expression in the inhibitory neurons of infralimbic cortex regulates the specificity of fear memory in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sarah A SternCenter for Neural Science, New York University, New York, NY, USA.
Cristina M Alberini
Icahn School of Medicine at Mount Sinai · USNew York University · US

Funding

Gene Expression in Long-Term MemoryR01MH065635 · NIMH · NEW YORK UNIVERSITY · PI CRISTINA M ALBERINI · 2002 to 2026
$7.5M
Gene Expression in Long-Term MemoryR37MH065635 · NIMH · NEW YORK UNIVERSITY · PI ALBERINI, CRISTINA M · 2013 to 2022
$5.6M
Mechanism Underlying Memory StabilizationR01MH074736 · NIMH · NEW YORK UNIVERSITY · PI ALBERINI, CRISTINA M · 2007 to 2016
$5.0M
Training Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0M
Astrocytic Contributions to Long Term Memory & Synaptic PlasticityF31MH090636 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STERN, SARAH · 2010 to 2014
$134k
NIMH NIH HHS F31 MH090636NIMH NIH HHS F31-MH090636NIMH NIH HHS R01 MH065635NIMH NIH HHS R01-MH065635NIMH NIH HHS R01 MH074736NIMH NIH HHS R01-MH074736NIMH NIH HHS R37 MH065635NIMH NIH HHS T32 MH087004
6 · The paper itself

Abstract

The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many of the same mechanisms, including CREB activation, AMPA/NMDA receptor trafficking, neuromodulation (e.g., via dopamine, adrenaline, cortisol, or acetylcholine) and metabolic processes (e.g., via glucose and insulin) may all lead to the enhancement of memory. These and other mechanisms and/or approaches have been tested via genetic or pharmacological methods in animal models, and several have been investigated in humans as well. In addition, a number of behavioral methods, including exercise and reconsolidation, may also serve to strengthen and enhance memories. By utilizing this information and continuing to investigate these promising avenues, memory enhancement may indeed be achieved in the future.

Indexed as

AnimalsCognitive Behavioral TherapyExercise TherapyHumansMemoryMemory DisordersNeurotransmitter AgentsNeurotransmitter Agents

Identifiers

PMID23151999
PMCPMC3527655
OpenAlexW1972492266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.