ArticleHuman brain mapping2014
Stochastic dynamic causal modeling of working memory connections in cocaine dependence.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The research progress on effective connectivity in adolescent depression based on resting-state fMRI.Frontiers in neurology · 2025Pooled it
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Altered effective connectivity of the reward network during an incentive-processing task in adults with alcohol use disorder.Alcoholism, clinical and experimental research · 2021Article
- Parallel cortical-brainstem pathways to attentional analgesia.NeuroImage · 2021Article
- Dynamic Causal Modeling Self-Connectivity Findings in the Functional Magnetic Resonance Imaging Neuropsychiatric Literature.Frontiers in neuroscience · 2021Review
- Network failures: When incentives trigger impulsive responses.Human brain mapping · 2020Article
- Altered Effective Connectivity of Central Autonomic Network in Response to Negative Facial Expression in Adults With Cannabis Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration.Brain structure & function · 2019Article
- Fronto-striatal effective connectivity of working memory in adults with cannabis use disorder.Psychiatry research. Neuroimaging · 2018Article
- Altered anterior cingulate cortex to hippocampus effective connectivity in response to drug cues in men with cocaine use disorder.Psychiatry research. Neuroimaging · 2018Article
- Dynamic network dysfunction in cocaine dependence: Graph theoretical metrics and stop signal reaction time.NeuroImage. Clinical · 2018Article
- PPARγ agonism attenuates cocaine cue reactivity.Addiction biology · 2018Article
- Distress tolerance among substance users is associated with functional connectivity between prefrontal regions during a distress tolerance task.Addiction biology · 2017Article
- Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia.Neuroscience bulletin · 2017Article
- The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder.Frontiers in psychology · 2017Review
- A debate on working memory and cognitive control: can we learn about the treatment of substance use disorders from the neural correlates of anorexia nervosa?BMC psychiatry · 2016Article
- Effective Connectivity within the Mesocorticolimbic System during Resting-State in Cocaine Users.Frontiers in human neuroscience · 2016Article
- Modeling Causal Relationship Between Brain Regions Within the Drug-Cue Processing Network in Chronic Cocaine Smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Inhibitory behavioral control: a stochastic dynamic causal modeling study using network discovery analysis.Brain connectivity · 2015Article
- Effect of cocaine dependence on brain connections: clinical implications.Expert review of neurotherapeutics · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although reduced working memory brain activation has been reported in several brain regions of cocaine-dependent subjects compared with controls, very little is known about whether there is altered connectivity of working memory pathways in cocaine dependence. This study addresses this issue by using functional magnetic resonance imaging-based stochastic dynamic causal modeling (DCM) analysis to study the effective connectivity of 19 cocaine-dependent subjects and 14 healthy controls while performing a working memory task. Stochastic DCM is an advanced method that has recently been implemented in SPM8 that can obtain improved estimates, relative to deterministic DCM, of hidden neuronal causes before convolution with the hemodynamic response. Thus, stochastic DCM may be less influenced by the confounding effects of variations in blood oxygen level-dependent response caused by disease or drugs. Based on the significant regional activation common to both groups and consistent with previous working memory activation studies, seven regions of interest were chosen as nodes for DCM analyses. Bayesian family level inference, Bayesian model selection analyses, and Bayesian model averaging (BMA) were conducted. BMA showed that the cocaine-dependent subjects had large differences compared with the control subjects in the strengths of prefrontal-striatal modulatory (B matrix) DCM parameters. These findings are consistent with altered cortical-striatal networks that may be related to reduced dopamine function in cocaine dependence. As far as we are aware, this is the first between-group DCM study using stochastic methodology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.