ArticleMolecules (Basel, Switzerland)2012
Investigation of the biological properties of (hetero)aromatic thiosemicarbazones.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential.Cancer medicine · 2025Pooled it
- Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties.Journal of enzyme inhibition and medicinal chemistry · 2026Article
- IntegratedPharmaceuticals (Basel, Switzerland) · 2026Article
- Synthesis of thiosemicarbazone Schiff base derivatives as anti-leishmanial agents and molecular dynamics simulations insights.Scientific reports · 2025Article
- Chemical composition, antioxidant activities and antibacterial activities of essential oil fromHeliyon · 2021Article
- Influence of Complexation of Thiosemicarbazone Derivatives with Cu (II) Ions on Their Antitumor Activity against Melanoma Cells.International journal of molecular sciences · 2021Article
- Copper(II) Thiosemicarbazone Complexes and Their Proligands upon UVA Irradiation: An EPR and Spectrophotometric Steady-State Study.Molecules (Basel, Switzerland) · 2018Article
- Article
- Repurposing an inhibitor of ribosomal biogenesis with broad anti-fungal activity.Scientific reports · 2017Article
- Crystal structure ofActa crystallographica. Section E, Crystallographic communications · 2017Article
- Crystal structure of 1-(4-formyl-benzyl-idene)-4-methyl-thio-semicarbazone.Acta crystallographica. Section E, Structure reports online · 2014Article
- Crystal structure of 1-(4-formyl-benzyl-idene)thio-semicarbazone.Acta crystallographica. Section E, Structure reports online · 2014Article
- Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides.Molecules (Basel, Switzerland) · 2014Article
- Article
- Antimycobacterial and photosynthetic electron transport inhibiting activity of ring-substituted 4-arylamino-7-chloroquinolinium chlorides.Molecules (Basel, Switzerland) · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two series of thiosemicarbazone-based iron chelators (twenty-seven compounds) were designed and synthesized using a microwave-assisted approach. Quinoline and halogenated phenyl were selected as parent scaffolds on the basis of a similarity search. The lipophilicity of the synthesized compounds was measured using HPLC and then calculated. Primary in vitro screening of the synthesized compounds was performed against eight pathogenic fungal strains. Only a few compounds showed moderate activity against fungi, and (E)-2-(quinolin-2-ylvinyl)-N,N-dimethylhydrazine-carbothioamide appeared to be more effective than fluconazole against most of the fungal strains tested. Antiproliferative activity was measured using a human colon cancer cell line (HCT-116). Several of the tested compounds showed submicromolar antiproliferative activity. Compounds were also tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The structure-activity relationships are discussed for all of the compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.