ReviewAutonomic neuroscience : basic & clinical2012
New insights into the effects of age and sex on arterial baroreflex function at rest and during dynamic exercise in humans.
Review in Autonomic neuroscience : basic & clinical, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men.The Journal of physiology · 2018Trial
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Baroreflex and chemoreflex interaction in high-altitude exposure: possible role on exercise performance.Frontiers in physiology · 2024Review
- Hypobaric hypoxia and cardiac baroreflex sensitivity in young women.American journal of physiology. Heart and circulatory physiology · 2022Article
- Effects of resistance training on baroreflex sensitivity function in healthy males.Journal of physical therapy science · 2022Article
- Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in healthy adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Hemodynamic characteristics and early warnings in very old patients.American journal of translational research · 2021Review
- Central autonomic network functional connectivity: correlation with baroreflex function and cardiovascular variability in older adults.Brain structure & function · 2020Article
- Gender Differences in Hemodynamic Regulation and Cardiovascular Adaptations to Dynamic Exercise.Current cardiology reviews · 2020Review
- Characterization of the Asymmetry of the Cardiac and Sympathetic Arms of the Baroreflex From Spontaneous Variability During Incremental Head-Up Tilt.Frontiers in physiology · 2019Article
- Baroreflex gain and vasomotor sympathetic modulation in resistant hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Article
- Arterial Pressure, Heart Rate, and Cerebral Hemodynamics Across the Adult Life Span.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Impaired carotid baroreflex control of arterial blood pressure in multiple sclerosis.Journal of neurophysiology · 2016Article
- Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans.American journal of physiology. Heart and circulatory physiology · 2015Article
- Passive Leg Raising Correlates with Future Exercise Capacity after Coronary Revascularization.PloS one · 2015Article
- An afferent explanation for sexual dimorphism in the aortic baroreflex of rat.American journal of physiology. Heart and circulatory physiology · 2014Article
- Yes! Sex matters: sex, the brain and blood pressure.Current hypertension reports · 2014Review
- Effect of aging on carotid baroreflex control of blood pressure and leg vascular conductance in women.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The arterial baroreflex (ABR) performs an important role in regulating blood pressure (BP) both at rest and during exercise, by carefully orchestrating autonomic neural activity to the heart and blood vessels. Reduced ABR sensitivity (i.e., gain) has been associated with increased cardiovascular risk, cardiac electrical instability and orthostatic intolerance, while 'normal' ABR function during exercise is important for ensuring an appropriate cardiovascular response is elicited. Previous studies examining the influence of age and sex on resting ABR function in humans have primarily used pharmacological methods (e.g., modified Oxford technique) to change BP and alter baroreceptor input. With this approach only reflex control of heart rate and sympathetic nerve activity may be evaluated, and as such the influence of age and sex on ABR control of BP per se remains incompletely understood. Furthermore, the majority of previous studies examining ABR function during exercise have principally assessed young men. Whether these findings can be extrapolated to young women or older men and women remains unclear. Recently the potential for age and sex to modulate the integrative neural control of the cardiovascular system is becoming appreciated. This review article will provide a detailed update of such recent advances into our understanding of the effects of age and sex on ABR control of BP both at rest and during dynamic exercise in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.