ArticleBMJ open2012
Assessment of simple risk markers for early mortality among HIV-infected patients in Guinea-Bissau: a cohort study.
Article in BMJ open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Determining a global mid-upper arm circumference cut-off to assess underweight in adults (men and non-pregnant women).Public health nutrition · 2020Pooled it
- Mid-upper arm circumference cut-offs identifying malnourishment and risk of mortality among patients with tuberculosis.BMC public health · 2025Observational
- Soluble Urokinase Plasminogen Activator Receptor as a Decision Marker for Early Discharge of Patients with COVID-19 Symptoms in the Emergency Department.The Journal of emergency medicine · 2021Observational
- suPAR Cut-Offs for Risk Stratification in Patients With Symptoms of COVID-19.Biomarker insights · 2021Article
- Plasma (1 → 3)-β-D-glucan and suPAR levels correlate with neurocognitive performance in people living with HIV on antiretroviral therapy: a CHARTER analysis.Journal of neurovirology · 2019Article
- HIV-2 as a model to identify a functional HIV cure.AIDS research and therapy · 2019Review
- Soluble Urokinase Plasminogen Activator Receptor Is Predictive of Non-AIDS Events During Antiretroviral Therapy-mediated Viral Suppression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Observational
- Article
- The validity of mid-upper arm circumference as an indicator of low BMI in population screening for undernutrition: a study among adult slum dwellers in eastern India.Public health nutrition · 2018Article
- Article
- Prevalence and predictors of low muscle mass in HIV/viral hepatitis coinfection.AIDS (London, England) · 2016Article
- Article
- Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark.AIDS research and human retroviruses · 2016Article
- High prevalence and excess mortality of late presenters among HIV-1, HIV-2 and HIV-1/2 dually infected patients in Guinea-Bissau - a cohort study from West Africa.The Pan African medical journal · 2016Article
- Better adherence to pre-antiretroviral therapy guidelines after implementing an electronic medical record system in rural Kenyan HIV clinics: a multicenter pre-post study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015Article
- High Prevalence of Severe Food Insecurity and Malnutrition among HIV-Infected Adults in Senegal, West Africa.PloS one · 2015Article
- Association between chronic hepatitis C virus infection and low muscle mass in US adults.Journal of viral hepatitis · 2014Article
- Factors associated with mortality in HIV-infected people in rural and urban South Africa.Global health action · 2014Article
- Trends and determinants of mortality in women of reproductive age in rural Guinea-Bissau, West Africa--a cohort study.BMC women's health · 2013Article
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDecisions about when to start an antiretroviral therapy (ART) are normally based on CD4 cell counts and viral load (VL). However, these measurements require equipment beyond the capacity of most laboratories in low-income and middle-income settings. Thus, there is an urgent need to identify and test simple markers to guide the optimal time for starting and for monitoring the effect of ART in developing countries.
objectives(1) To evaluate anthropometric measurements and measurement of plasma-soluble form of the urokinase plasminogen activator receptor (suPAR) levels as potential risk factors for early mortality among HIV-infected patients; (2) to assess whether these markers could help identify patients to whom ART should be prioritised and (3) to determine if these markers may add information to CD4 cell count when VL is not available.
designAn observational study.
settingThe largest ART centre in Bissau, Guinea-Bissau.
participants1083 ART-naïve HIV-infected patients. OUTCOME MEASURES: Associations between baseline anthropometric measurements, CD4 cell counts, plasma suPAR levels and survival were examined using Cox proportional hazards models.
resultsLow body mass index (BMI≤18.5 kg/m(2)), low mid-upper-arm-circumference (MUAC≤250 mm), low CD4 cell count (≤350 cells/μl) and high suPAR plasma levels (>5.3 ng/ml) were independent predictors of death. Furthermore, mortality among patients with low CD4 cell count, low MUAC or low BMI was concentrated in the highest suPAR quartile.
conclusionsIrrespective of ART initiation and baseline CD4 count, MUAC and suPAR plasma levels were independent predictors of early mortality in this urban cohort. These markers could be useful in identifying patients at the highest risk of short-term mortality and may aid triage for ART when CD4 cell count is not available or when there is shortness of antiretroviral drugs.
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Registered trials
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