ArticleBMC medical genomics2012
Completion of the swine genome will simplify the production of swine as a large animal biomedical model.
Article in BMC medical genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
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- Biochar improves lettuce seedling growth by influencing the nutrient content of simulated lunar soil.iScience · 2025Article
- Centers for Medical Countermeasures against Radiation Consortium: Past, Present, and Beyond.Radiation research · 2025Review
- A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ion transport and epithelial barrier dysfunction in experimental models of ulcerative colitis.American journal of physiology. Gastrointestinal and liver physiology · 2025Review
- Prebiotics and Probiotics Supplementation in Pigs as a Model for Human Gut Health and Disease.Biomolecules · 2025Review
- Current Techniques of Gene Editing in Pigs for Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Generation and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders.Cell & bioscience · 2024Article
- Retinal transplant immunology and advancements.Stem cell reports · 2024Review
- Association Analysis ofGenes · 2022Article
- Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.Scientific reports · 2022Article
- Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease.Frontiers in veterinary science · 2022Review
- A porcine brain-wide RNA editing landscape.Communications biology · 2021Article
- Human small intestinal organotypic culture model for drug permeation, inflammation, and toxicity assays.In vitro cellular & developmental biology. Animal · 2021Review
- A decade of experience with genetically tailored pig models for diabetes and metabolic research.Animal reproduction · 2020Review
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- Improvement of in vitro and early in utero porcine clone development after somatic donor cells are cultured under hypoxia.Molecular reproduction and development · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease.
methodsCloning from a modified somatic cell, which can be determined in cells prior to making the animal, is the only method available for the production of targeted modifications in swine.
resultsSince some strains of swine are similar in size to humans, technologies that have been developed for swine can be readily adapted to humans and vice versa. Here the importance of swine as a biomedical model, current technologies to produce genetically enhanced swine, current biomedical models, and how the completion of the swine genome will promote swine as a biomedical model are discussed.
conclusionsThe completion of the swine genome will enhance the continued use and development of swine as models of human health, syndromes and conditions.
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Registered trials
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