Trial reportCritical care (London, England)2012
Can neonatal lung ultrasound monitor fluid clearance and predict the need of respiratory support?
Trial report in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04253951 (Lung Ultrasound for Early Detection of Silent and Apparent aspiratioN in Infants and Young CHildren With Cerebral Palsy and Other Developmental Disabilities), which is not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Ultrasound for Early Detection of Silent and Apparent aspiratioN in Infants and Young CHildren With Cerebral Palsy and Other Developmental Disabilities: a New Fast, Safe, Cost-effective Infant-friendly Imaging Tool to Easily Monitor Feeding , Improve Outcomes and Reduce Morbidities (LUNCH)
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Efficacy of oral sucrose for preterm infants undergoing point-of-care lung ultrasound: a randomized assessor-blinded controlled trial.European journal of pediatrics · 2026Trial
- Introduction of point-of-care neonatal lung ultrasound in a developing country.European journal of pediatrics · 2020Trial
- Early indicators of NICU admission for ongoing respiratory support in caesarean-delivered late preterm and term neonates requiring non-invasive respiratory support within the first 15 min after birth: a post hoc analysis.BMJ paediatrics open · 2026Article
- Effects of Neurally Adjusted Ventilatory Assist on Lung Ultrasound Aeration and Diaphragmatic Function in Extremely Preterm Infants With Evolving or Established Bronchopulmonary Dysplasia.Pediatric pulmonology · 2026Observational
- Beyond ductal closure: interpreting the TREOCAPA trial in the evolving management of patent ductus arteriosus in preterm infants.Translational pediatrics · 2026Article
- Early lung ultrasound at one hour of life and subsequent oxygen requirement during the first 48 h after birth: a prospective observational study.Italian journal of pediatrics · 2026Observational
- Validation of Lung Ultrasound Score for Disease Severity and Outcomes in Pediatric Acute Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026Observational
- Inter-rater agreement of a newborn calf lung ultrasound scoring system.Journal of veterinary internal medicine · 2026Article
- Observational
- Lung Ultrasound for Predicting Resolution of Transient Tachypnea of the Newborn: A Diagnostic Accuracy Study.CHEST pulmonary · 2025Article
- Lung Ultrasound in Neonatal Respiratory Distress Syndrome: A Narrative Review of the Last 10 Years.Diagnostics (Basel, Switzerland) · 2024Review
- Proportion of confluent B-Lines predicts respiratory support in term infants shortly after birth.Respiratory research · 2024Observational
- Article
- Lung ultrasound for prediction of surfactant requirement in Indian preterm neonates: a diagnostic accuracy study.European journal of pediatrics · 2024Article
- Delivery Room Lung Ultrasound-Feasibility, Normal Patterns, and Predictive Value for Respiratory Support in Term and Near-Term Neonates: A Monocentric Study.Life (Basel, Switzerland) · 2024Article
- Review
- Neonatal point-of-care lung ultrasound: what should be known and done out of the NICU?European journal of pediatrics · 2024Review
- The best of both worlds: Refining respiratory phenotypes through combined non-invasive lung monitoring.Pediatric research · 2024Article
- Lung ultrasound for the sick child: less harm and more information than a radiograph.European journal of pediatrics · 2024Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAt birth, lung fluid is rapidly cleared to allow gas exchange. As pulmonary sonography discriminates between liquid and air content, we have used it to monitor extrauterine fluid clearance and respiratory adaptation in term and late preterm neonates. Ultrasound data were also related to the need for respiratory support.
methodsConsecutive infants at 60 to 120 minutes after birth underwent lung echography. Images were classified using a standardized protocol of adult emergency medicine with minor modifications. Neonates were assigned to type 1 (white lung image), type 2 (prevalence of comet-tail artifacts or B-lines) or type 3 profiles (prevalence of horizontal or A lines). Scans were repeated at 12, 24 and 36 hours. The primary endpoint was the number of infants admitted to the neonatal ICU (NICU) by attending staff who were unaware of the ultrasound. Mode of respiratory support was also recorded.
resultsA total of 154 infants were enrolled in the study. Fourteen neonates were assigned to the type 1, 46 to the type 2 and 94 to the type 3 profile. Within 36 hours there was a gradual shift from types 1 and 2 to type 3. All 14 type 1 and 4 type 2 neonates were admitted to the NICU. Sensitivity was 77.7%, specificity was 100%, positive predictive value was 100%, negative predictive value was 97%. Four type 1 infants were mechanically ventilated.
conclusionsIn the late preterm and term neonate, the lung ultrasound scan follows a reproducible pattern that parallels the respiratory status and can be used as a predictor of respiratory support.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.