ArticleScience signaling2012
Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5.
Article in Science signaling, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- TRAF6 coiled-coil domain mediates its trimerization.bioRxiv : the preprint server for biology · 2025Article
- TRAF1 from a Structural Perspective.Biomolecules · 2024Review
- Negative Regulatory Role of the Spring Viremia of Carp Virus Matrix Protein in the Host Interferon Response by Targeting the MAVS/TRAF3 Signaling Axis.Journal of virology · 2022Article
- TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity.Communications biology · 2021Article
- Structural feature of TRAFs, their related human diseases and therapeutic intervention.Archives of pharmacal research · 2021Review
- Rv3722c PromotesFrontiers in cellular and infection microbiology · 2021Article
- Comparison of Target Recognition by TRAF1 and TRAF2.International journal of molecular sciences · 2020Article
- Thioredoxin 2 Negatively Regulates Innate Immunity to RNA Viruses by Disrupting the Assembly of the Virus-Induced Signaling Adaptor Complex.Journal of virology · 2020Article
- Article
- Structure of TRAF Family: Current Understanding of Receptor Recognition.Frontiers in immunology · 2018Review
- Negative Regulation of Interferon-β Production by Alternative Splicing of Tumor Necrosis Factor Receptor-Associated Factor 3 in Ducks.Frontiers in immunology · 2018Article
- MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner.PLoS pathogens · 2017Article
- Molecular basis for unique specificity of human TRAF4 for platelets GPIbβ and GPVI.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry.Biochimica et biophysica acta · 2016Review
- Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5.Protein science : a publication of the Protein Society · 2016Article
- Crystal structure of TRAF1 TRAF domain and its implications in the TRAF1-mediated intracellular signaling pathway.Scientific reports · 2016Article
- Structural Insights into mitochondrial antiviral signaling protein (MAVS)-tumor necrosis factor receptor-associated factor 6 (TRAF6) signaling.The Journal of biological chemistry · 2015Article
- A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway.Biophysical journal · 2015Article
- The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The TRAF [tumor necrosis factor receptor-associated factor] family of cytoplasmic adaptor proteins link cell-surface receptors to intracellular signaling pathways that regulate innate and adaptive immune responses. In response to activation of RIG-I (retinoic acid-inducible gene I), a component of a pattern recognition receptor that detects viruses, TRAF3 binds to the adaptor protein Cardif [caspase activation and recruitment domain (CARD) adaptor-inducing interferon-β (IFN-β)], leading to induction of type I IFNs. We report the crystal structures of the TRAF domain of TRAF5 and that of TRAF3 bound to a peptide from the TRAF-interacting motif of Cardif. By comparing these structures, we identified two residues located near the Cardif binding pocket in TRAF3 (Tyr(440) and Phe(473)) that potentially contributed to Cardif recognition. In vitro and cellular experiments showed that forms of TRAF5 with mutation of the corresponding residues to those of TRAF3 had TRAF3-like antiviral activity. Our results provide a structural basis for the critical role of TRAF3 in activating RIG-I-mediated IFN production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.