ReviewOxidative medicine and cellular longevity2012
Cocoa polyphenols and their potential benefits for human health.
Review in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Effects of Cocoa-Derived Polyphenols on Cognitive Function in Humans. Systematic Review and Analysis of Methodological Aspects.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Pooled it
- Acute effects of cocoa flavanols on visual working memory: maintenance and updating.European journal of nutrition · 2022Trial
- Gene expression changes by high-polyphenols cocoa powder intake: a randomized crossover clinical study.European journal of nutrition · 2019Trial
- Dark Chocolate Intake Positively Modulates Redox Status and Markers of Muscular Damage in Elite Football Athletes: A Randomized Controlled Study.Oxidative medicine and cellular longevity · 2018Trial
- Maternal restriction of polyphenols and fetal ductal dynamics in normal pregnancy: an open clinical trial.Arquivos brasileiros de cardiologia · 2013Trial
- Potential Application of Cocoa Extract in Preventing Skin Cancer Through Inhibition of Adenosine Receptor A2, VEGFR-2, and BCL-2:Medeniyet medical journal · 2026Article
- Phenolic Profile and Antioxidant Activity of Chocolates Supplemented with Bioactive Ingredients.Foods (Basel, Switzerland) · 2026Article
- Development and Validation of a Rapid High-Performance Liquid Chromatography Method for Simultaneous Determination of Methylxanthines and Flavanols in Cocoa Husk Tea.Molecules (Basel, Switzerland) · 2026Article
- Cocoa Supplementation Alleviates Gliadin-Induced Intestinal Dysbiosis in a Mouse Model of Celiac Disease.Foods (Basel, Switzerland) · 2026Article
- The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review.Nutrients · 2025Review
- Modulation of Gut Microbiota by Cacao: Insights from an In Vitro Model.Current issues in molecular biology · 2025Article
- Purification of Flavonoids from an Aqueous Cocoa (Molecules (Basel, Switzerland) · 2025Article
- Unveiling the Potential Neuroprotective Effect of Bioactive Compounds from Plants with Sedative and Mood-Modulating Properties: Innovative Approaches for the Prevention of Alzheimer's and Parkinson's Diseases.Current neuropharmacology · 2025Review
- The impact of diet and oral hygiene on dental caries among Turkish children: A cross-sectional study.PloS one · 2025Article
- Regulation of aging-related chronic diseases by dietary polyphenols: An updated overview.Current research in food science · 2025Review
- Chocolate intake and risk of type 2 diabetes: prospective cohort studies.BMJ (Clinical research ed.) · 2024Article
- Concentrating Cocoa Polyphenols-Clarification of an Aqueous Cocoa Extract by Protein Precipitation and Filtration.Membranes · 2024Article
- Exploring variations in quality parameters ofHeliyon · 2024Article
- Exploring the Therapeutic Potential ofAntioxidants (Basel, Switzerland) · 2024Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper compiles the beneficial effects of cocoa polyphenols on human health, especially with regard to cardiovascular and inflammatory diseases, metabolic disorders, and cancer prevention. Their antioxidant properties may be responsible for many of their pharmacological effects, including the inhibition of lipid peroxidation and the protection of LDL-cholesterol against oxidation, and increase resistance to oxidative stress. The phenolics from cocoa also modify the glycemic response and the lipid profile, decreasing platelet function and inflammation along with diastolic and systolic arterial pressures, which, taken together, may reduce the risk of cardiovascular mortality. Cocoa polyphenols can also modulate intestinal inflammation through the reduction of neutrophil infiltration and expression of different transcription factors, which leads to decreases in the production of proinflammatory enzymes and cytokines. The phenolics from cocoa may thus protect against diseases in which oxidative stress is implicated as a causal or contributing factor, such as cancer. They also have antiproliferative, antimutagenic, and chemoprotective effects, in addition to their anticariogenic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.