ArticleJournal of allergy2012
Neuronal modulation of airway and vascular tone and their influence on nonspecific airways responsiveness in asthma.
Article in Journal of allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review.Frontiers in physiology · 2025Pooled it
- Neonatal rhinorrhea, heart rate variability, and childhood exercise-induced wheeze.The journal of allergy and clinical immunology. Global · 2023Article
- Exhaled Nitric Oxide and Pulmonary Oxygen Toxicity Susceptibility.Metabolites · 2023Article
- Metformin prevents airway hyperreactivity in rats with dietary obesity.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Enhanced airway sensory nerve reactivity in non-eosinophilic asthma.BMJ open respiratory research · 2021Article
- Increased Heart Rate Variability Response Among Infants with Reported Rhinorrhea and Watery Eyes: A Pilot Study.Journal of asthma and allergy · 2021Article
- School environment associates with lung function and autonomic nervous system activity in children: a cross-sectional study.Scientific reports · 2019Article
- Airway Innervation and Plasticity in Asthma.Physiology (Bethesda, Md.) · 2019Review
- Dexmedetomidine's inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation.BMC anesthesiology · 2017Article
- Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma.American journal of respiratory and critical care medicine · 2016Observational
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- Morphologic Characterization of Nerves in Whole-Mount Airway Biopsies.American journal of respiratory and critical care medicine · 2015Article
- The gain of smooth muscle's contractile capacity induced by tone on in vivo airway responsiveness in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Article
- Severe asthma in horses is associated with increased airway innervation.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autonomic nervous system provides both cholinergic and noncholinergic neural inputs to end organs within the airways, which includes the airway and vascular smooth muscle. Heightened responsiveness of the airways to bronchoconstrictive agents is a hallmark feature of reactive airways diseases. The mechanisms underpinning airways hyperreactivity still largely remain unresolved. In this paper we summarize the substantial body of evidence that implicates dysfunction of the autonomic nerves that innervate smooth muscle in the airways and associated vasculature as a prominent cause of airways hyperresponsiveness in asthma.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.