ArticleThe Journal of biological chemistry2012
An advanced glycation end product (AGE)-receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein function.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice.Adipocyte · 2026Article
- Molecular Mechanisms of Interaction of Human Serum Albumin with the CD36 Receptor: Insights from Molecular Dynamics Simulations.International journal of molecular sciences · 2026Article
- A novel obesity index reveals obesity-associated microbiota changes after weight loss intervention in a Spanish population.Nutrition journal · 2026Article
- Adipocytes as core drivers of skin aging and novel targets for regeneration.Biogerontology · 2026Review
- Therapeutic potential of copper II oxide in treating diabetic wounds: an emerging approach for enhanced healing.Acta diabetologica · 2026Review
- The Evolution of Gallic Acid in Aged White Tea and Its Potential Anti-Aging Mechanisms: An Integrated Study Combining Network Pharmacology and Computer Simulation.Food science & nutrition · 2025Article
- Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress.Journal of molecular histology · 2024Review
- Molecular Basis for the Involvement of Mammalian Serum Albumin in the AGE/RAGE Axis: A Comprehensive Computational Study.International journal of molecular sciences · 2024Article
- Protein components of maple syrup as a potential resource for the development of novel anti‑colorectal cancer drugs.Oncology reports · 2023Article
- Receptor for the Advanced Glycation End Products (International journal of molecular sciences · 2023Review
- Development of thiazole-appended novel hydrazones as a new class of α-amylase inhibitors with anticancer assets: anRSC medicinal chemistry · 2023Article
- Maternal helminth infection protects offspring from high-fat-diet-induced obesity through altered microbiota and SCFAs.Cellular & molecular immunology · 2023Article
- Recent advances in responsive hydrogels for diabetic wound healing.Materials today. Bio · 2023Review
- Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice.Aging cell · 2022Article
- How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature.International journal of nanomedicine · 2022Review
- The metabolic roots of senescence: mechanisms and opportunities for intervention.Nature metabolism · 2021Review
- Diabetic Pneumopathy-A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations.Frontiers in endocrinology · 2021Review
- The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing.Oxidative medicine and cellular longevity · 2021Review
- Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy.International journal of molecular sciences · 2019Article
- Adipose-derived Stem Cells Attenuates Diabetic Osteoarthritis via Inhibition of Glycation-mediated Inflammatory Cascade.Aging and disease · 2019Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impaired adipogenic potential of senescent preadipocytes is a hallmark of adipose aging and aging-related adipose dysfunction. Although advanced glycation end products (AGEs) derived from both foods and endogenous nonenzymatic glycation and AGE-associated signaling pathways are known to play a key role in aging and its related diseases, the role of AGEs in adipose aging remains elusive. We show a novel pro-adipogenic function of AGEs in replicative senescent preadipocytes and mouse embryonic fibroblasts, as well as primary preadipocytes isolated from aged mice. Using glycated bovine serum albumin (BSA) as a model protein of AGEs, we found that glycated BSA restores the impaired adipogenic potential of senescent preadipocytes in vitro and ex vivo. However, glycated BSA showed no effect on adipogenesis in nonsenescent preadipocytes. The AGE-induced receptor for AGE (RAGE) expression is required for the pro-adipogenic function of AGEs in senescent preadipocytes. RAGE is required for impairment of p53 expression and p53 function in regulating p21 expression in senescent preadipocytes. We also observed a direct binding between RAGE and p53 in senescent preadipocytes. Taken together, our findings reveal a novel pro-adipogenic function of the AGE-RAGE axis in p53-regulated adipogenesis of senescent preadipocytes, providing new insights into aging-dependent adiposity by diet-driven and/or endogenous glycated proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.