ArticleThe Plant cell2012
Identification and characterization of an epi-allele of FIE1 reveals a regulatory linkage between two epigenetic marks in rice.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 154 citations in OpenAlex.
- DNA Methylation Dynamics in Plant Abiotic Stress Response: Mechanisms, Memory, and Breeding Applications.Genes · 2026Review
- Loss of function of chromatin remodeler OsCLSY4 leads to RdDM-mediated mis-expression of endosperm-specific genes affecting grain qualities.PLoS genetics · 2025Article
- DNA Methylation in Rice: Mechanisms, Regulatory Roles, and Beyond.International journal of molecular sciences · 2025Review
- Maternally expressed FERTILIZATION-INDEPENDENT ENDOSPERM1 regulates seed dormancy and aleurone development in rice.The Plant cell · 2024Article
- Upstream regulator of genomic imprinting in rice endosperm is a small RNA-associated chromatin remodeler.Nature communications · 2024Article
- Mapping parental DMRs predictive of local and distal methylome remodeling in epigenetic F1 hybrids.Life science alliance · 2024Article
- GW9 determines grain size and floral organ identity in rice.Plant biotechnology journal · 2024Article
- Transcriptome-wide identification and characterization of genes exhibit allele-specific imprinting in maize embryo and endosperm.BMC plant biology · 2023Article
- Heritable responses to stress in plants.Quantitative plant biology · 2023Review
- Exploitation of epigenetic variation of crop wild relatives for crop improvement and agrobiodiversity preservation.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Review
- A coiled-coil protein associates Polycomb Repressive Complex 2 with KNOX/BELL transcription factors to maintain silencing of cell differentiation-promoting genes in the shoot apex.The Plant cell · 2022Article
- Fine mapping and candidate gene analysis of dwarf gene Rht14 in durum wheat (Triticum durum).Functional & integrative genomics · 2022Article
- DNA demethylation affects imprinted gene expression in maize endosperm.Genome biology · 2022Article
- Harnessing epigenetic variability for crop improvement: current status and future prospects.Genes & genomics · 2022Review
- Epigenome editing: targeted manipulation of epigenetic modifications in plants.Genes & genomics · 2022Review
- Will epigenetics be a key player in crop breeding?Frontiers in plant science · 2022Review
- Epigenetics and its role in effecting agronomical traits.Frontiers in plant science · 2022Review
- Separable regulation of POW1 in grain size and leaf angle development in rice.Plant biotechnology journal · 2021Article
- Assessment of natural DNA methylation variation and its association with economically important traits in dolichos bean (Lablab purpureus L. Var. Lignosus) using AMP-PCR assay.Journal of applied genetics · 2021Article
- Review
6 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation and histone H3 Lys 9 dimethylation (H3K9me2) are important epigenetic repression marks for silencing transposons in heterochromatin and for regulating gene expression. However, the mechanistic relationship to other repressive marks, such as histone H3 Lys 27 trimethylation (H3K27me3) is unclear. FERTILIZATION-INDEPENDENT ENDOSPERM1 (FIE1) encodes an Esc-like core component of the Polycomb repressive complex 2, which is involved in H3K27me3-mediated gene repression. Here, we identify a gain-of-function epi-allele (Epi-df) of rice (Oryza sativa) FIE1; this allele causes a dwarf stature and various floral defects that are inherited in a dominant fashion. We found that Epi-df has no changes in nucleotide sequence but is hypomethylated in the 5' region of FIE1 and has reduced H3K9me2 and increased H3K4me3. In Epi-df, FIE1 was ectopically expressed and its imprinting was disrupted. FIE1 interacted with rice Enhancer of Zeste homologs, consistent with its role in H3K27me3 repression. Ectopic expression of FIE1 in Epi-df resulted in alteration of H3K27me3 levels in hundreds of genes. In summary, this work identifies an epi-allele involved in H3K27me3-mediated gene repression that itself is highly regulated by DNA methylation and histone H3K9me2, thereby shedding light on the link between DNA methylation and histone methylation, the two important epigenetic marks regulating rice development.
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