ArticleInvestigative ophthalmology & visual science2012
In vivo confocal intrinsic optical signal identification of localized retinal dysfunction.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 33 citations in OpenAlex.
- Evaluating Human Rod Photoreceptor Function Using Pixelwise Intensity-Based Optoretinography.Translational vision science & technology · 2026Article
- ƒ(Cell): Software for Reproducible Analysis of Optoretinograms.Translational vision science & technology · 2026Article
- The Role of Medical Image Modalities and AI in the Early Detection, Diagnosis and Grading of Retinal Diseases: A Survey.Bioengineering (Basel, Switzerland) · 2022Review
- Super-resolution ophthalmoscopy: Virtually structured detection for resolution improvement in retinal imaging.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Functional optical coherence tomography of retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Functional optical coherence tomography of neurovascular coupling interactions in the retina.Journal of biophotonics · 2018Article
- Light-Induced Length Shrinkage of Rod Photoreceptor Outer Segments.Translational vision science & technology · 2018Article
- In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation.Journal of biomedical optics · 2018Article
- Comparative investigation of stimulus-evoked rod outer segment movement and retinal electrophysiological activity.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors.Biomedical optics express · 2017Article
- Concurrent OCT imaging of stimulus evoked retinal neural activation and hemodynamic responses.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- In vivo super-resolution retinal imaging through virtually structured detection.Journal of biomedical optics · 2016Article
- In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas.Journal of biomedical optics · 2016Article
- Stimulus-evoked outer segment changes in rod photoreceptors.Journal of biomedical optics · 2016Article
- Biophysical mechanism of transient retinal phototropism in rod photoreceptors.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Article
- Imaging the adult zebrafish cone mosaic using optical coherence tomography.Visual neuroscience · 2016Article
- Intrinsic optical signal imaging of retinal physiology: a review.Journal of biomedical optics · 2015Review
- Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purposes of this study were to investigate the physiological mechanism of stimulus-evoked fast intrinsic optical signals (IOSs) recorded in dynamic confocal imaging of the retina, and to demonstrate the feasibility of in vivo confocal IOS mapping of localized retinal dysfunctions.
methodsA rapid line-scan confocal ophthalmoscope was constructed to achieve in vivo confocal IOS imaging of frog (Rana pipiens) retinas at cellular resolution. In order to investigate the physiological mechanism of confocal IOS, comparative IOS and electroretinography (ERG) measurements were made using normal frog eyes activated by variable-intensity stimuli. A dynamic spatiotemporal filtering algorithm was developed to reject the contamination of hemodynamic changes on fast IOS recording. Laser-injured frog eyes were employed to test the potential of confocal IOS mapping of localized retinal dysfunctions.
resultsComparative IOS and ERG experiments revealed a close correlation between the confocal IOS and retinal ERG, particularly the ERG a-wave, which has been widely used to evaluate photoreceptor function. IOS imaging of laser-injured frog eyes indicated that the confocal IOS could unambiguously detect localized (30 μm) functional lesions in the retina before a morphological abnormality is detectable.
conclusionsThe confocal IOS predominantly results from retinal photoreceptors, and can be used to map localized photoreceptor lesion in laser-injured frog eyes. We anticipate that confocal IOS imaging can provide applications in early detection of age-related macular degeneration, retinitis pigmentosa, and other retinal diseases that can cause pathological changes in the photoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.