ArticleProceedings of the National Academy of Sciences of the United States of America2012
Linking ligand perception by PEPR pattern recognition receptors to cytosolic Ca2+ elevation and downstream immune signaling in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 157 citations in OpenAlex.
- Rice phospholipase C4 enhances CaPlant communications · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- Arabidopsis thaliana Cyclic Nucleotide-Gated Channel 19 is involved in root extracellular ATP and Pep1 signalling.The New phytologist · 2025Article
- Article
- Plant Immunity: At the Crossroads of Pathogen Perception and Defense Response.Plants (Basel, Switzerland) · 2024Review
- The secreted PAMP-induced peptide StPIP1_1 activates immune responses in potato.Scientific reports · 2023Article
- Paradigms of receptor kinase signaling in plants.The Biochemical journal · 2023Review
- Small Signals Lead to Big Changes: The Potential of Peptide-Induced Resistance in Plants.Journal of fungi (Basel, Switzerland) · 2023Review
- CaThe EMBO journal · 2022Review
- New Horizons in Plant Cell Signaling.International journal of molecular sciences · 2022Article
- A tale of many families: calcium channels in plant immunity.The Plant cell · 2022Review
- Thirty years of resistance: Zig-zag through the plant immune system.The Plant cell · 2022Review
- An efficient and broadly applicable method for transient transformation of plants using vertically aligned carbon nanofiber arrays.Frontiers in plant science · 2022Article
- Melatonin Protects Tobacco Suspension Cells against Pb-Induced Mitochondrial Dysfunction.International journal of molecular sciences · 2021Article
- Electrical Signaling of Plants under Abiotic Stressors: Transmission of Stimulus-Specific Information.International journal of molecular sciences · 2021Review
- Deciphering the Role of Ion Channels in Early Defense Signaling against Herbivorous Insects.Cells · 2021Review
- Screening forSTAR protocols · 2021Article
- Moonlighting Proteins Shine New Light on Molecular Signaling Niches.International journal of molecular sciences · 2021Review
- The Complex Story of Plant Cyclic Nucleotide-Gated Channels.International journal of molecular sciences · 2021Review
- Plant Defense Responses to Biotic Stress and Its Interplay With Fluctuating Dark/Light Conditions.Frontiers in plant science · 2021Review
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about molecular steps linking perception of pathogen invasion by cell surface sentry proteins acting as pattern recognition receptors (PRRs) to downstream cytosolic Ca(2+) elevation, a critical step in plant immune signaling cascades. Some PRRs recognize molecules (such as flagellin) associated with microbial pathogens (pathogen-associated molecular patterns, PAMPs), whereas others bind endogenous plant compounds (damage-associated molecular patterns, DAMPs) such as peptides released from cells upon attack. This work focuses on the Arabidopsis DAMPs plant elicitor peptides (Peps) and their receptors, PEPR1 and PEPR2. Pep application causes in vivo cGMP generation and downstream signaling that is lost when the predicted PEPR receptor guanylyl cyclase (GC) active site is mutated. Pep-induced Ca(2+) elevation is attributable to cGMP activation of a Ca(2+) channel. Some differences were identified between Pep/PEPR signaling and the Ca(2+)-dependent immune signaling initiated by the flagellin peptide flg22 and its cognate receptor Flagellin-sensing 2 (FLS2). FLS2 signaling may have a greater requirement for intracellular Ca(2+) stores and inositol phosphate signaling, whereas Pep/PEPR signaling requires extracellular Ca(2+). Maximal FLS2 signaling requires a functional Pep/PEPR system. This dependence was evidenced as a requirement for functional PEPR receptors for maximal flg22-dependent Ca(2+) elevation, H(2)O(2) generation, defense gene [WRKY33 and Plant Defensin 1.2 (PDF1.2)] expression, and flg22/FLS2-dependent impairment of pathogen growth. In a corresponding fashion, FLS2 loss of function impaired Pep signaling. In addition, a role for PAMP and DAMP perception in bolstering effector-triggered immunity (ETI) is reported; loss of function of either FLS2 or PEPR receptors impaired the hypersensitive response (HR) to an avirulent pathogen.
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