ArticleAnnals of biomedical engineering2013
Temporal healing in rat achilles tendon: ultrasound correlations.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Characterizing tendon microstructure using metrics associated with the angular dependence of ultrasound backscatter.The Journal of the Acoustical Society of America · 2026Article
- Preventing peritendinous adhesions using lubricious supramolecular hydrogels.Nature communications · 2026Article
- Ultrasound histogram metrics for subscapularis tendon: Toward standardized musculoskeletal image interpretation.Medicine · 2026Article
- Near-normal ultrasound morphology in quadriceps tendon after anterior cruciate ligament graft harvest.Journal of experimental orthopaedics · 2025Article
- Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Leucine rich repeat containing 32 accelerates tenogenic differentiation of tendon-derived stem cells and promotes Achilles tendon repair in rats.Experimental animals · 2023Article
- Periostin modulates extracellular matrix behavior in tendons.Matrix biology plus · 2022Article
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- A numerical framework for mechano-regulated tendon healing-Simulation of early regeneration of the Achilles tendon.PLoS computational biology · 2021Article
- Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Tendon healing affects the multiscale mechanical, structural and compositional response of tendon to quasi-static tensile loading.Journal of the Royal Society, Interface · 2018Article
- Temporal Healing of Achilles Tendons After Injury in Rodents Depends on Surgical Treatment and Activity.The Journal of the American Academy of Orthopaedic Surgeons · 2017Article
- Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics.Scientific reports · 2017Article
- Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing.Scientific reports · 2017Article
- Nonsurgical treatment and early return to activity leads to improved Achilles tendon fatigue mechanics and functional outcomes during early healing in an animal model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Males have Inferior Achilles Tendon Material Properties Compared to Females in a Rodent Model.Annals of biomedical engineering · 2016Article
- Periostin as a multifunctional modulator of the wound healing response.Cell and tissue research · 2016Review
- Ultrasound assessment of ex vivo lung tissue properties using a fluid-filled negative pressure bath.Journal of biomechanical engineering · 2014Article
- The Achilles tendon: fundamental properties and mechanisms governing healing.Muscles, ligaments and tendons journal · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The purpose of this study was to explore whether a new ultrasound-based technique correlates with mechanical and biological metrics that describe the tendon healing. Achilles tendons in 32 rats were unilaterally transected and allowed to heal without repair. At 7, 9, 14, or 29 days post-injury, tendons were collected and examined for healing via ultrasound image analysis, mechanical testing, and immunohistochemistry. Consistent with previous studies, we observe that the healing tendons are mechanically inferior (ultimate stress, ultimate load, and normalized stiffness) and biologically altered (cellular and ECM factors) compared to contralateral controls with an incomplete recovery over healing time. Unique to this study, we report: (1) Echo intensity (defined by gray-scale brightness in the ultrasound image) in the healing tissue is related to stress and normalized stiffness. (2) Elongation to failure is relatively constant so that tissue normalized stiffness is linearly correlated with ultimate stress. Together, 1 and 2 suggest a method to quantify mechanical compromise in healing tendons. (3) The amount and type of collagen in healing tendons associates with their strength and normalized stiffness as well as their ultrasound echo intensity. (4) A significant increase of periostin in the healing tissues suggests an important but unexplored role for this ECM protein in tendon healing.
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Registered trials
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