SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Gender differences in the diagnostic accuracy of SPECT myocardial perfusion imaging: a bivariate meta-analysis.
Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Sex-based differences in myocardial perfusion imaging among diabetic Egyptian patients:a retrospective registry study.Global cardiology science & practice · 2026Article
- Clinical determinants of agreement and discordance between stress SPECT and invasive coronary angiography.Frontiers in cardiovascular medicine · 2026Article
- Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography.European heart journal. Cardiovascular Imaging · 2024Article
- Role of non-invasive coronary imaging in stable angina.Global cardiology science & practice · 2024Review
- Position Statement on Ischemic Heart Disease - Women-Centered Health Care - 2023.Arquivos brasileiros de cardiologia · 2023Article
- Imaging of heart disease in women: review and case presentation.European journal of nuclear medicine and molecular imaging · 2022Review
- Multimodality Imaging in the Detection of Ischemic Heart Disease in Women.Journal of cardiovascular development and disease · 2022Review
- Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging.Medicina (Kaunas, Lithuania) · 2022Article
- Can myocardial perfusion imaging predict outcome in patients with angina and ischemia but no obstructive coronary artery disease (INOCA)?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The additive prognostic value of coronary calcium score (CCS) to single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI)-real world data from a single center.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Effects of gender and defect reversibility on detection of coronary disease with an upright and supine cadmium-zinc-telluride camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Vitamin D Deficiency as a Risk Factor for Myocardial Ischemia.Medicina (Kaunas, Lithuania) · 2021Article
- State of the Art in Noninvasive Imaging of Ischemic Heart Disease and Coronary Microvascular Dysfunction in Women: Indications, Performance, and Limitations.Current atherosclerosis reports · 2020Review
- The role of imaging in women with ischemic heart disease.Clinical cardiology · 2018Review
- The role of pharmacological stress testing in women.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Multi-modality Imaging: Bird's eye view from the 2015 American Heart Association Scientific Sessions.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Women-specific factors to consider in risk, diagnosis and treatment of cardiovascular disease.Women's health (London, England) · 2015Review
- Diagnostic performance and comparative cost-effectiveness of non-invasive imaging tests in patients presenting with chronic stable chest pain with suspected coronary artery disease: a systematic overview.Current cardiology reports · 2014Review
- Gender differences in the evaluation of coronary artery disease with a cadmium-zinc telluride camera.European journal of nuclear medicine and molecular imaging · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
backgroundIt remains controversial whether the diagnostic accuracy of single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) is different in men as compared to women. We performed a meta-analysis to investigate gender differences of SPECT MPI for the diagnosis of CAD (≥50% stenosis).
methodTwo investigators independently performed a systematic review of the MEDLINE and EMBASE databases from inception through January 2012 for English-language studies determining the diagnostic accuracy of SPECT MPI. We included prospective studies that compared SPECT MPI with conventional coronary angiography which provided sufficient data to calculate gender-specific true and false positives and negatives. Data from studies evaluating <20 patients of one gender were excluded. Bivariate meta-analysis was used to create summary receiver operating curves.
resultsTwenty-six studies met inclusion criteria, representing 1,148 women and 1,142 men. Bivariate meta-analysis yielded a mean sensitivity and specificity of 84.2% (95% confidence interval [CI] 78.7%-88.6%) and 78.7% (CI 70.0%-85.3%) for SPECT MPI in women and 89.1% (CI 84.0%-92.7%) and 71.2% (CI 60.8%-79.8%) for SPECT MPI in men. There was no significant difference in the sensitivity (P = .15) or specificity (P = .23) between male and female subjects.
conclusionIn a bivariate meta-analysis of the available literature, the diagnostic accuracy of SPECT MPI is similar for both men and women.
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