ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2012
Emerging risk factors for postpartum depression: serotonin transporter genotype and omega-3 fatty acid status.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Causal effects of neuroticism on postpartum depression: a bidirectional mendelian randomization study.Archives of women's mental health · 2024Pooled it
- Screening for individuals with postpartum depression by an attenuated and delayed niacin skin flushing response: a case control study.BMC pregnancy and childbirth · 2025Article
- Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity.Neurobiology of stress · 2024Article
- Maternal Diet Quality and Prenatal Depressive Symptoms: The Moderating Role of Economic Well-Being.Nutrients · 2023Article
- Review
- Antenatal and Postnatal Maternal Depressive Symptoms and Trajectories and Child Hospitalization up to 24 Months of Life: Findings From the 2015 Pelotas (Brazil) Birth Cohort Study.The journal of pediatrics: X · 2021Article
- Pathophysiological mechanisms implicated in postpartum depression.Frontiers in neuroendocrinology · 2019Review
- The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly.Current neuropharmacology · 2018Review
- Determinants of polyunsaturated fatty acid concentrations in erythrocytes of pregnant Japanese women from a birth cohort study: study protocol and baseline findings of an adjunct study of the Japan environment & Children's study.Environmental health and preventive medicine · 2017Article
- Serum n-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy.Epidemiology and psychiatric sciences · 2017Article
- Postpartum depression risk factors: A narrative review.Journal of education and health promotion · 2017Review
- Postpartum depression: A systematic review of the genetics involved.World journal of psychiatry · 2015Review
- Pharmacotherapy of postpartum depression: an update.Expert opinion on pharmacotherapy · 2014Review
- Correlation between n-3 polyunsaturated fatty acids consumption and BDNF peripheral levels in adolescents.Lipids in health and disease · 2014Article
- Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression.PloS one · 2013Article
- Postpartum depression: psychoneuroimmunological underpinnings and treatment.Neuropsychiatric disease and treatment · 2013Article
- Association between Vitamin D Levels During Pregnancy and Postpartum Depression: A Narrative Reviews.Iranian journal of nursing and midwifery researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDepression is a leading cause of disability and hospitalization. Women are at the highest risk of depression during their childbearing years, and the birth of a child may precipitate a depressive episode in vulnerable women. Postpartum depression (PPD) is associated with diminished maternal somatic health as well as health and developmental problems in their offspring. This review focuses on 2 PPD risk factors of emerging interest: serotonin transporter (5-HTT) genotype and omega-3 polyunsaturated fatty acid (n-3 PUFA) status.
methodThe MEDLINE, PubMed, and Web of Science databases were searched using the key words postpartum depression, nutrition, omega-3 fatty acids, and serotonin transporter gene. Studies were also located by reviewing the reference lists of selected articles.
resultsSeventy-five articles were identified as relevant to this review. Three carefully conducted studies reported associations between the 5-HTT genotype and PPD. As well, there is accumulating evidence that n-3 PUFA intake is associated with risk of PPD. Preliminary evidence suggests that there could be an interaction between these 2 emerging risk factors. However, further studies are required to confirm such an interaction and to elucidate the underlying mechanisms.
conclusionsEvidence to date supports a research agenda clarifying the associations between n-3 PUFAs, the 5-HTT genotype, and PPD. This is of particular interest owing to the high prevalence of poor n-3 PUFA intake among women of childbearing age and the consequent potential for alternative preventive measures and treatments for PPD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.