ArticleAntioxidants & redox signaling2013
Functional analysis of Arabidopsis mutants points to novel roles for glutathione in coupling H(2)O(2) to activation of salicylic acid accumulation and signaling.
Article in Antioxidants & redox signaling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed.
- Sulfur metabolism-dependent retrograde signaling for oxidative stress acclimation.Journal of experimental botany · 2026Review
- Reactive Oxygen Species in Crop Plants: Production, Detoxification, Signaling, and Molecular Cross-Talk.Plants (Basel, Switzerland) · 2026Review
- Interaction with CYP20-3 limits OPDA flux into jasmonate biosynthesis in wounded leaves of arabidopsis grown at eCOFrontiers in plant science · 2026Article
- The nicotinamide hypothesis revisited-plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione.FEBS letters · 2025Review
- The redox rhythm gates immune-induced cell death distinctly from the genetic clock.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Proteomic analysis reveals dynamic expression related to malondialdehyde in cassava in response to cassava bacterial blight.Scientific reports · 2025Article
- Redox-signaling in innate immune memory: Similar mechanisms in animals/humans and plants.Redox biology · 2025Review
- Unraveling key genes and pathways involved in Verticillium wilt resistance by integrative GWAS and transcriptomic approaches in Upland cotton.Functional & integrative genomics · 2025Article
- The role of salicylic acid in modulating phenotyping in spring wheat varieties for mitigating drought stress.BMC plant biology · 2024Article
- Cadmium toxicity promotes hormonal imbalance and induces the expression of genes involved in systemic resistances in barley.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Decoding early stress signaling waves in living plants using nanosensor multiplexing.Nature communications · 2024Article
- Sulfate Availability and Hormonal Signaling in the Coordination of Plant Growth and Development.International journal of molecular sciences · 2024Review
- Glutathione-the "master" antioxidant in the regulation of resistant and susceptible host-plant virus-interaction.Frontiers in plant science · 2024Review
- Polystyrene nanoparticles induce concerted response of plant defense mechanisms in plant cells.Scientific reports · 2023Article
- Article
- Plant Life with and without Oxygen: A Metabolomics Approach.International journal of molecular sciences · 2023Review
- Glutathione Contribution in Interactions betweenInternational journal of molecular sciences · 2023Article
- Redox Signaling in Plant Heat Stress Response.Antioxidants (Basel, Switzerland) · 2023Review
- Crosstalk between melatonin and reactive oxygen species in fruits and vegetables post-harvest preservation: An update.Frontiers in nutrition · 2023Review
- Glutathione imparts stress tolerance againstPlant signaling & behavior · 2022Article
47 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
aimsThrough its interaction with H(2)O(2), glutathione is a candidate for transmission of signals in plant responses to pathogens, but identification of signaling roles is complicated by its antioxidant function. Using a genetic approach based on a conditional catalase-deficient Arabidopsis mutant, cat2, this study aimed at establishing whether GSH plays an important functional role in the transmission of signals downstream of H(2)O(2).
resultsIntroducing the cad2 or allelic mutations in the glutathione synthesis pathway into cat2 blocked H(2)O(2)-triggered GSH oxidation and accumulation. While no effects on NADP(H) or ascorbate were observed, and H(2)O(2)-induced decreases in growth were maintained, blocking GSH modulation antagonized salicylic acid (SA) accumulation and SA-dependent responses. Other novel double and triple mutants were produced and compared with cat2 cad2 at the levels of phenotype, expression of marker genes, nontargeted metabolite profiling, accumulation of SA, and bacterial resistance. Most of the effects of the cad2 mutation on H(2)O(2)-triggered responses were distinct from those produced by mutations for GLUTATHIONE REDUCTASE1 (GR1) or NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), and were linked to compromised induction of ISOCHORISMATE SYNTHASE1 (ICS1) and ICS1-dependent SA accumulation. INNOVATION: A novel genetic approach was used in which GSH content or antioxidative capacity was independently modified in an H(2)O(2) signaling background. Analysis of new double and triple mutants allowed us to infer previously undescribed regulatory roles for GSH.
conclusionIn parallel to its antioxidant role, GSH acts independently of NPR1 to allow increased intracellular H(2)O(2) to activate SA signaling, a key defense response in plants.
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