ArticleThe Journal of cell biology2012
A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment.
Article in The Journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Review
- Insertion of mNeonGreen into the variable domain of DRP-1 permits visualization of functional endogenous protein.microPublication biology · 2025Article
- The Mitochondrial Distribution and Morphology Family 33 GeneJournal of fungi (Basel, Switzerland) · 2024Article
- Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division.iScience · 2024Article
- Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome.Life science alliance · 2024Article
- Molecular Basis of Mitochondrial and Peroxisomal Division Machineries.International journal of molecular sciences · 2020Review
- Mitochondrial Inheritance in Phytopathogenic Fungi-Everything Is Known, or Is It?International journal of molecular sciences · 2020Review
- Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission.Scientific reports · 2018Article
- Mitochondrial dynamics: The dynamin superfamily and execution by collusion.Seminars in cell & developmental biology · 2018Review
- A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission.The Journal of biological chemistry · 2016Article
- MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe oryzae.PLoS pathogens · 2016Article
- The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1.Molecular biology of the cell · 2015Article
- Splitting up the powerhouse: structural insights into the mechanism of mitochondrial fission.Cellular and molecular life sciences : CMLS · 2015Review
- A dynamin-related protein contributes to Trichomonas vaginalis hydrogenosomal fission.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Specific interaction with cardiolipin triggers functional activation of Dynamin-Related Protein 1.PloS one · 2014Article
- Dynamin assembly strategies and adaptor proteins in mitochondrial fission.Current biology : CB · 2013Review
- Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
To initiate mitochondrial fission, dynamin-related proteins (DRPs) must bind specific adaptors on the outer mitochondrial membrane. The structural features underlying this interaction are poorly understood. Using yeast as a model, we show that the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1. Mutation of this conserved motif specifically disrupted Dnm1-Mdv1 interactions, blocking Dnm1 recruitment and mitochondrial fission. Suppressor mutations in Mdv1 that restored Dnm1-Mdv1 interactions and fission identified potential protein-binding interfaces on the Mdv1 β-propeller domain. These results define the first known function for Insert B in DRP-adaptor interactions. Based on the variability of Insert B sequences and adaptor proteins, we propose that Insert B domains and mitochondrial adaptors have coevolved to meet the unique requirements for mitochondrial fission of different organisms.
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