ArticleThe Journal of biological chemistry2012
A Na+/Ca2+ exchanger-like protein (AtNCL) involved in salt stress in Arabidopsis.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 124 citations in OpenAlex.
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- Glycolysis and signal transduction participate in Lycium barbarum in response to NaCl stress through protein phosphorylation.BMC plant biology · 2025Article
- An Integrated Method for Evaluation of Salt Tolerance in a Tall Wheatgrass Breeding Program.Plants (Basel, Switzerland) · 2025Article
- New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels.Frontiers in plant science · 2025Article
- Genome-wide association study of salt tolerance in sorghum during germination.Frontiers in plant science · 2025Article
- Comparative Analysis of CaPlants (Basel, Switzerland) · 2024Article
- Mechanisms by Which Exogenous Substances Enhance Plant Salt Tolerance through the Modulation of Ion Membrane Transport and Reactive Oxygen Species Metabolism.Antioxidants (Basel, Switzerland) · 2024Review
- Involvement of GLR-mediated nitric oxide effects on ROS metabolism in Arabidopsis plants under salt stress.Journal of plant research · 2024Article
- Types of Membrane Transporters and the Mechanisms of Interaction between Them and Reactive Oxygen Species in Plants.Antioxidants (Basel, Switzerland) · 2024Review
- Genome-Wide Association Study of Starch Properties in Local Thai Rice.Plants (Basel, Switzerland) · 2023Article
- Transcriptomic Insight into the Pollen Tube Growth ofPlants (Basel, Switzerland) · 2023Article
- Membrane Proteins in Plant Salinity Stress Perception, Sensing, and Response.The Journal of membrane biology · 2023Review
- HvNCX, a prime candidate gene for the novel qualitative locus qS7.1 associated with salinity tolerance in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Calcium signalling in weeds under herbicide stress: An outlook.Frontiers in plant science · 2023Article
- Co-application of proline or calcium and humic acid enhances productivity of salt stressed pomegranate by improving nutritional status and osmoregulation mechanisms.Scientific reports · 2022Article
- Role ofLife (Basel, Switzerland) · 2022Article
- A Putative Plasma Membrane NaFrontiers in plant science · 2022Article
- Calcium channels and transporters: Roles in response to biotic and abiotic stresses.Frontiers in plant science · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium ions (Ca(2+)) play a crucial role in many key physiological processes; thus, the maintenance of Ca(2+) homeostasis is of primary importance. Na(+)/Ca(2+) exchangers (NCXs) play an important role in Ca(2+) homeostasis in animal excitable cells. Bioinformatic analysis of the Arabidopsis genome suggested the existence of a putative NCX gene, Arabidopsis NCX-like (AtNCL), encoding a protein with an NCX-like structure and different from Ca(2+)/H(+) exchangers and Na(+)/H(+) exchangers previously identified in plant. AtNCL was identified to localize in the Arabidopsis cell membrane fraction, have the ability of binding Ca(2+), and possess NCX-like activity in a heterologous expression system of cultured mammalian CHO-K1 cells. AtNCL is broadly expressed in Arabidopsis, and abiotic stresses stimulated its transcript expression. Loss-of-function atncl mutants were less sensitive to salt stress than wild-type or AtNCL transgenic overexpression lines. In addition, the total calcium content in whole atncl mutant seedlings was higher than that in wild type by atomic absorption spectroscopy. The level of free Ca(2+) in the cytosol and Ca(2+) flux at the root tips of atncl mutant plants, as detected using transgenic aequorin and a scanning ion-selective electrode, required a longer recovery time following NaCl stress compared with that in wild type. All of these data suggest that AtNCL encodes a Na(+)/Ca(2+) exchanger-like protein that participates in the maintenance of Ca(2+) homeostasis in Arabidopsis. AtNCL may represent a new type of Ca(2+) transporter in higher plants.
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