Evidence map›Paper›PMID 23147574›Full record

ReviewNature reviews. Endocrinology2013

The role of osteocalcin in human glucose metabolism: marker or mediator?

Sarah L Booth, Amanda Centi, Steven R Smith, Caren Gundberg

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 121 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 3 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01972113 naunknown statusnot on this map

Vitamin K and Glucose Metabolism in Children at Risk for Diabetes

TypeinterventionalSponsorAugusta UniversityRan2013 to 2020Enrolled30ConditionsObesity, Insulin Resistance, Insulin Sensitivity, PrediabetesArmsPlacebo-Control, Low-Dose Vitamin K2 (menaquinone-7, 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7, 90 mcg/d)
NCT02366481 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes

TypeinterventionalSponsorAugusta UniversityRan2015 to 2020Enrolled30ConditionsObesity, Insulin Resistance, Insulin Sensitivity, Beta-Cell DysfunctionArmsPlacebo, Low-Dose Vitamin K2 Supplement (menaquinone-7, 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7, 180-mcg/d)
3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 3 syntheses or guidelines pooled it, 220 citations in OpenAlex.

  1. The effect of exercise training on osteocalcin, adipocytokines, and insulin resistance: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  2. Pooled it
  3. Association between osteocalcin and glucose metabolism: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Pooled it
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  13. Comparison of the effect of 18-month daily teriparatide administration on patients with rheumatoid arthritis and postmenopausal osteoporosis patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Trial
  14. Review
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  19. Observational
  20. Osteocalcin and frailty among older women.Aging clinical and experimental research · 2025
    Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sarah L BoothJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. sarah.booth@tufts.edu
Amanda Centi
Steven R Smith
Caren Gundberg
Boston University · USSanford Burnham Prebys Medical Discovery Institute · USYale University · US

Funding

OSTEOCALCIN SYNTHESIS AND CATABOLISM IN VIVO AND IN VITRR01AR038460 · NIAMS · YALE UNIVERSITY · PI GUNDBERG, CAREN · 1986 to 2007
$2.5M
Dietary &non-dietary components of vitamin K metabolismR01DK069341 · NIDDK · TUFTS UNIVERSITY BOSTON · PI BOOTH, SARAH LOUISE · 2005 to 2008
$1.7M
VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSISR01AG014759 · NIA · TUFTS UNIVERSITY BOSTON · PI BOOTH, SARAH · 1998 to 2001
$610k
NIAMS NIH HHS AR38460NIAMS NIH HHS R01 AR038460NIA NIH HHS AG14759NIA NIH HHS R01 AG014759NIDDK NIH HHS DK69341NIDDK NIH HHS P30 DK04735NIDDK NIH HHS R01 DK069341
6 · The paper itself

Abstract

Increasing evidence supports an association between the skeleton and energy metabolism. These interactions are mediated by a variety of hormones, cytokines and nutrients. Here, the evidence for a role of osteocalcin in the regulation of glucose metabolism in humans is reviewed. Osteocalcin is a bone matrix protein that regulates hydroxyapatite size and shape through its vitamin-K-dependent, γ-carboxylated form. The concentration of osteocalcin in the circulation is a measure of bone formation. The undercarboxylated form of osteocalcin is active in glucose metabolism in mice. Total serum osteocalcin concentrations in humans are inversely associated with measures of glucose metabolism; however, human data are inconclusive with regard to the role of uncarboxylated osteocalcin in glucose metabolism because most studies do not account for the influence of vitamin K on the proportion of undercarboxylated osteocalcin or differentiate between the total and uncarboxylated forms of osteocalcin. Furthermore, most human studies do not concomitantly measure other bone turnover markers to isolate the role of osteocalcin as a measure of bone formation from its effect on glucose metabolism. Carefully designed studies are required to define the role of osteocalcin and its carboxylated or undercarboxylated forms in the regulation of glucose metabolism in humans.

Indexed as

AnimalsEnergy MetabolismGlucoseHumansOsteocalcinGlucoseOsteocalcin

Identifiers

PMID23147574
PMCPMC4441272
OpenAlexW2060546728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.