ArticleInfection and immunity2013
Cloning and characterization of rainbow trout interleukin-17A/F2 (IL-17A/F2) and IL-17 receptor A: expression during infection and bioactivity of recombinant IL-17A/F2.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- Modulation of Master Transcription Factor Expression of Nile Tilapia Leukocytes via Cholinergic Pathways.International journal of molecular sciences · 2025Article
- Identification and functional characterization of fish IL-17 receptors suggest important roles in the response to nodavirus infection.Marine life science & technology · 2024Article
- Identification and Expression Analysis of LncRNAs Reveal the Immune Mechanism of Visceral White-Nodules Disease Resistance in Large Yellow Croaker.Marine biotechnology (New York, N.Y.) · 2023Article
- A defective interleukin-17 receptor A1 causes weight loss and intestinal metabolism-related gene downregulation in Japanese medaka, Oryzias latipes.Scientific reports · 2021Article
- The Evolution and Diversity of Interleukin-17 Highlight an Expansion in Marine Invertebrates and Its Conserved Role in Mucosal Immunity.Frontiers in immunology · 2021Article
- Expression and Function Analysis of Interleukin-17A/F1, 2, and 3 Genes in Yellow Catfish (Frontiers in immunology · 2021Article
- A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout.Parasite immunology · 2020Review
- Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon.Biology · 2020Article
- Interleukin-17 suppresses grass carp reovirus infection inAquaculture (Amsterdam, Netherlands) · 2020Article
- Identification and Regulation of Interleukin-17 (IL-17) Family Ligands in the Teleost Fish European Sea Bass.International journal of molecular sciences · 2020Article
- Interleukin-17A/F1 Deficiency Reduces Antimicrobial Gene Expression and Contributes to Microbiome Alterations in Intestines of Japanese medaka (Frontiers in immunology · 2020Article
- Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass CarpFrontiers in immunology · 2020Article
- Integration of Transcriptome, Gross Morphology and Histopathology in the Gill of Sea Farmed Atlantic Salmon (Frontiers in genetics · 2020Article
- CD4: a vital player in the teleost fish immune system.Veterinary research · 2019Review
- Transcriptome-wide mapping of signaling pathways and early immune responses in lumpfish leukocytes upon in vitro bacterial exposure.Scientific reports · 2018Article
- Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture.Frontiers in immunology · 2018Article
- Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio).PloS one · 2018Article
- Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional Characterization of Two DivergentFrontiers in immunology · 2018Article
- A transcriptome analysis focusing on inflammation-related genes of grass carp intestines following infection with Aeromonas hydrophila.Scientific reports · 2017Article
- The Function of Fish Cytokines.Biology · 2016Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower vertebrates have been found to possess genes that have similar homology to both interleukin (IL)-17A and IL-17F, which have been termed IL-17A/F. In fish species, several of these genes can be present, but, to date, very little is known about their functional activity. This article describes the discovery and sequence analysis of a rainbow trout (Oncorhynchus mykiss) IL-17A/F2 molecule and an IL-17RA receptor. In addition, the bioactivity of the trout IL-17A/F2 is investigated for the first time in any species. The predicted IL-17A/F2 and IL-17RA proteins consist of 146 and 966 amino acids (aa), respectively, with both molecules containing conserved family motifs. Expression analysis revealed high constitutive expression of trout IL-17A/F2 in mucosal tissues from healthy fish, suggesting a potential role in mucosal immunity. When the modulation of IL-17A/F2 and IL-17RA in vitro was analyzed, it was observed that the two molecules were similarly affected. The expression of IL-17A/F2 was also induced in head kidney during bacterial, parasitic, and viral infections, revealing a possible function in defense against such pathogens. However, downregulation of IL-17RA was seen in some tissues and infections. The recombinant IL-17A/F2 protein was produced in Escherichia coli and was found to affect the expression of an antimicrobial peptide and the proinflammatory cytokines IL-6 and IL-8 in splenocytes. Consistent with mammalian IL-17 homologues, our expression and bioactivity results imply that trout IL-17A/F2 plays an important role in promoting inflammatory and host innate immune responses directed against different pathogen groups.
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