ArticleBiology direct2012
ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons.
Article in Biology direct, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 56 citations in OpenAlex.
- Probe-based identification of metal-binding sites using deep learning representations.Nature communications · 2026Article
- Genomic and Functional Analysis of the ALOG Gene Family inPlants (Basel, Switzerland) · 2026Article
- Characterization and Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- Genome-wide identification and characterization ofFrontiers in plant science · 2025Article
- Genome-wide evolution and function analysis of ALOG gene family in cotton.Frontiers in genetics · 2025Article
- The ALOG domain defines a family of plant-specific transcription factors acting during Arabidopsis flower development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Expression profiling of ALOG family genes during inflorescence development and abiotic stress responses in rice (Frontiers in genetics · 2024Article
- Article
- Genome-wide identification and evolutionary view of ALOG gene family in Solanaceae.Genetics and molecular biology · 2023Article
- Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer.Journal of visualized experiments : JoVE · 2022Article
- Heterotypic transcriptional condensates formed by prion-like paralogous proteins canalize flowering transition in tomato.Genome biology · 2022Article
- ArabidopsisInternational journal of molecular sciences · 2021Article
- ROS regulated reversible protein phase separation synchronizes plant flowering.Nature chemical biology · 2021Article
- Molecular characterization of Arabidopsis thaliana LSH1 and LSH2 genes.Genes & genomics · 2020Article
- Genome-wide identification and characterization of the ALOG gene family in Petunia.BMC plant biology · 2019Article
- Fine mapping of a locus presumably involved in hybrid inviability (Breeding science · 2019Article
- Review
- Analysing the rice young panicle transcriptome reveals the gene regulatory network controlled by TRIANGULAR HULL1.Rice (New York, N.Y.) · 2019Article
- Genome-Wide Identification and Characterization of the ALOG Domain Genes in Rice.International journal of genomics · 2019Article
- Combining Three Mapping Strategies to Reveal Quantitative Trait Loci and Candidate Genes for Maize Ear Length.The plant genome · 2018Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the Arabidopsis LSH1 and Oryza G1 (ALOG) family of proteins have been shown to function as key developmental regulators in land plants. However, their precise mode of action remains unclear. Using sensitive sequence and structure analysis, we show that the ALOG domains are a distinct version of the N-terminal DNA-binding domain shared by the XerC/D-like, protelomerase, topoisomerase-IA, and Flp tyrosine recombinases. ALOG domains are distinguished by the insertion of an additional zinc ribbon into this DNA-binding domain. In particular, we show that the ALOG domain is derived from the XerC/D-like recombinases of a novel class of DIRS-1-like retroposons. Copies of this element, which have been recently inactivated, are present in several marine metazoan lineages, whereas the stramenopile Ectocarpus, retains an active copy of the same. Thus, we predict that ALOG domains help establish organ identity and differentiation by binding specific DNA sequences and acting as transcription factors or recruiters of repressive chromatin. They are also found in certain plant defense proteins, where they are predicted to function as DNA sensors. The evolutionary history of the ALOG domain represents a unique instance of a domain, otherwise exclusively found in retroelements, being recruited as a specific transcription factor in the streptophyte lineage of plants. Hence, they add to the growing evidence for derivation of DNA-binding domains of eukaryotic specific TFs from mobile and selfish elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.