Evidence map›Paper›PMID 23146026›Full record

ArticleAnalytical chemistry2012

Semitransparent nanostructured films for imaging mass spectrometry and optical microscopy.

Jay G Forsythe, Joshua A Broussard, Jenifer L Lawrie, Michal Kliman, Yang Jiao, Sharon M Weiss, Donna J Webb, John A McLean

Abstract read
In one paragraph

Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jay G ForsytheDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA.
Joshua A Broussard
Jenifer L Lawrie
Michal Kliman
Yang Jiao
Sharon M Weiss
Donna J Webb
John A McLean

Funding

TISSUE CoreP50CA098131 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PARK, BEN HO, PIETENPOL, JENNIFER A · 2003 to 2024
$48.7M
New Methodologies for Accelerating Natural Product DiscoveryR01GM092218 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, MCLEAN, JOHN ALAN · 2010 to 2018
$2.8M
Elucidation of Leukocyte and Macrophage Biomarker Signatures from Drugs of AbuseRC2DA028981 · NIDA · VANDERBILT UNIVERSITY · PI LIPSON, HOD, MCLEAN, JOHN ALAN · 2009 to 2010
$2.7M
TRAINING PROGRAM IN BREAST CANCER RESEARCHT32CA078136 · NCI · VANDERBILT UNIVERSITY · PI ARTEAGA, CARLOS L · 1998 to 2007
$2.4M
"A signaling integrator plays a critical role in regulating cell migration"R01GM092914 · NIGMS · VANDERBILT UNIVERSITY · PI WEBB, DONNA J · 2010 to 2013
$1.2M
NCI NIH HHS P50 CA098131NCI NIH HHS T32 CA078136NCI NIH HHS T32CA078136NIDA NIH HHS RC2 DA028981NIDA NIH HHS RC2DA028981NIGMS NIH HHS GM092914NIGMS NIH HHS R01 GM092218NIGMS NIH HHS R01GM092218NIGMS NIH HHS R01 GM092914
6 · The paper itself

Abstract

Semitransparent porous silicon substrates have been developed for pairing nanostructure-initiator mass spectrometry (NIMS) imaging with traditional optical-based microscopy techniques. Substrates were optimized to generate the largest NIMS signal while maintaining sufficient transparency to allow visible light to pass through for optical microscopy. Using these substrates, both phase-contrast and NIMS images of phospholipids from a scratch-wounded cell monolayer were obtained. NIMS images were generated using a spatial resolution of 14 μm. Coupled with further improvements in spatial resolution, this approach may allow for the localization of intact biological molecules within cells without the need for labeling.

Indexed as

Cell LineCell MovementHumansMass SpectrometryMicroscopy, Phase-ContrastNanostructuresOptical PhenomenaSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Identifiers

PMID23146026
PMCPMC3544556

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.