ArticleThe journal of physical chemistry. B2013
Tuning nanostructure dimensions with supramolecular twisting.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Bioactive Supramolecular Polymers for Skin Regeneration Following Burn Injury.Biomacromolecules · 2025Article
- Heating-Induced Switching to Hierarchical Liquid Crystallinity Combining Colloidal and Molecular Order in Zwitterionic Molecules.ACS omega · 2023Article
- Molecular Modulator Approach for Controlling the Length of Chiral 1D Single-Helical Gold Nanoparticle Superstructures.Chemistry of materials : a publication of the American Chemical Society · 2023Article
- Single Amino Acid Modifications for Controlling the Helicity of Peptide-Based Chiral Gold Nanoparticle Superstructures.Journal of the American Chemical Society · 2023Article
- Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles.Biomaterials science · 2023Article
- Energy Landscapes of Supramolecular Peptide-Drug Conjugates Directed by Linker Selection and Drug Topology.ACS nano · 2022Article
- Polymyxin B-Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy.Advanced healthcare materials · 2021Article
- Superstructured Biomaterials Formed by Exchange Dynamics and Host-Guest Interactions in Supramolecular Polymers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Design of materials with supramolecular polymers.Progress in polymer science · 2020Review
- Transition of Nano-Architectures Through Self-Assembly of Lipidated βFrontiers in chemistry · 2020Article
- Hierarchically oriented organization in supramolecular peptide crystals.Protein and peptide letters · 2019Article
- Actuation of magnetoelastic membranes in precessing magnetic fields.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Atheroma Niche-Responsive Nanocarriers for Immunotherapeutic Delivery.Advanced healthcare materials · 2019Article
- Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles.ACS applied materials & interfaces · 2019Article
- Supramolecular self assembly of nanodrill-like structures for intracellular delivery.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Drug-Bearing Supramolecular Filament Hydrogels as Anti-Inflammatory Agents.Theranostics · 2017Article
- Peptide-Directed Assembly of Single-Helical Gold Nanoparticle Superstructures Exhibiting Intense Chiroptical Activity.Journal of the American Chemical Society · 2016Article
- Building Nanostructures with Drugs.Nano today · 2016Article
- The powerful functions of peptide-based bioactive matrices for regenerative medicine.Annals of biomedical engineering · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Peptide amphiphiles are molecules containing a peptide segment covalently bonded to a hydrophobic tail and are known to self-assemble in water into supramolecular nanostructures with shape diversity ranging from spheres to cylinders, twisted ribbons, belts, and tubes. Understanding the self-assembly mechanisms to control dimensions and shapes of the nanostructures remains a grand challenge. We report here on a systematic study of peptide amphiphiles containing valine-glutamic acid dimeric repeats known to promote self-assembly into belt-like flat assemblies. We find that the lateral growth of the assemblies can be controlled in the range of 100 nm down to 10 nm as the number of dimeric repeats is increased from two to six. Using circular dichroism, the degree of β-sheet twisting within the supramolecular assemblies was found to be directly proportional to the number of dimeric repeats in the PA molecule. Interestingly, as twisting increased, a threshold is reached where cylinders rather than flat assemblies become the dominant morphology. We also show that in the belt regime, the width of the nanostructures can be decreased by raising the pH to increase charge density and therefore electrostatic repulsion among glutamic acid residues. The control of size and shape of these nanostructures should affect their functions in biological signaling and drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.