Evidence map›Paper›PMID 23145941›Full record

ArticleAIDS research and human retroviruses2013

Short communication: neutralizing antibodies in HIV-1-infected Brazilian individuals.

Dalziza Victalina Almeida, Mariza Gonçalvez Morgado, Fernanda Heloise Côrtes, Monick Lindermeyer Guimarães, Leila Mendonça-Lima, Jose Henrique Pilotto, Beatriz Grinsztejn, Valdiléa Gonçalves Veloso, Vera Bongertz

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dalziza Victalina AlmeidaAIDS and Molecular Immunology Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil. dalziza@gmail.com
Mariza Gonçalvez Morgado
Fernanda Heloise Côrtes
Monick Lindermeyer Guimarães
Leila Mendonça-Lima
Jose Henrique Pilotto
Beatriz Grinsztejn
Valdiléa Gonçalves Veloso
Vera Bongertz

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tests for the detection of the humoral immune response to HIV-1 have to be standardized and established, demanding regional efforts. For this purpose the neutralizing antibody (NAb) assay for HIV-1 in TZM-bl cells was introduced in Brazil. Twenty plasma samples from HIV-1-infected individuals were assayed: 10 progressors and 10 long-term nonprogressors. These were tested against eight env-pseudotyped viruses (psVs) in the TZM-bl NAb assay and against HIV-1 strain HTLV/IIIB (HIV-1 IIIB) in primary lymphocytes. Forty-four percent of the samples showed neutralizing titers for psVs and 55% for HIV-1 IIIB. Plasma from progressors showed a broader neutralization and a higher potency. The introduction of these reference reagents encourages the participation of Brazil in future comparative assessments of anti-HIV-1 antibodies.

Indexed as

Antibodies, NeutralizingBrazilFemaleHIV-1HIV AntibodiesHIV InfectionsHumansMaleNeutralization TestsAntibodies, NeutralizingHIV Antibodies

Identifiers

PMID23145941
PMCPMC3582229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.