ReviewBritish journal of clinical pharmacology2014
Long term outcomes of pharmacological treatments for opioid dependence: does methadone still lead the pack?
Review in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Alcohol use disorders are associated with increased HIV risk behaviors in cocaine-dependent methadone patients.Journal of substance abuse treatment · 2017Trial
- Long-term outcomes after randomization to buprenorphine/naloxone versus methadone in a multi-site trial.Addiction (Abingdon, England) · 2016Trial
- Pain volatility and prescription opioid addiction treatment outcomes in patients with chronic pain.Experimental and clinical psychopharmacology · 2015Trial
- Article
- The role of attachment and personality traits in choosing opiate addiction replacement therapy.Scientific reports · 2024Article
- L-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats.Scientific reports · 2024Article
- The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats.Frontiers in pharmacology · 2024Article
- Experiences of healthcare and substance use treatment provider-based stigma among patients receiving methadone.Drug and alcohol dependence reports · 2023Article
- L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats.Frontiers in pharmacology · 2023Article
- Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats.Frontiers in pharmacology · 2023Article
- Cumulative barriers to retention in methadone treatment among adults from rural and small urban communities.Addiction science & clinical practice · 2022Article
- Harm reduction in the time of COVID-19: Case study of homelessness and drug use in Dublin, Ireland.The International journal on drug policy · 2021Article
- High retention in an opioid agonist therapy project in Durban, South Africa: the role of best practice and social cohesion.Harm reduction journal · 2020Article
- Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.Scientific reports · 2020Article
- Six-month retention and changes in quality of life and substance use from a low-threshold methadone maintenance therapy programme in Durban, South Africa.Addiction science & clinical practice · 2020Article
- Opioid agonist therapy during residential treatment of opioid use disorder: Cohort study on access and outcomes.Canadian family physician Medecin de famille canadien · 2019Article
- Quality of primary care among individuals receiving treatment for opioid use disorder.Canadian family physician Medecin de famille canadien · 2019Article
- Co-Occurring Psychiatric and Substance Use Disorders: Clinical Survey Among a Rural Cohort of Italian Patients.Neuropsychiatric disease and treatment · 2019Article
- Factors Associated with Sustained Remission among Chronic Opioid Users.Addiction & health · 2018Article
- Empirical Studies Addressing the Opioid Epidemic: An Urgent Call for Research.Substance abuse : research and treatment · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this review was to update and summarize the scientific knowledge on the long term outcomes of the different pharmacological treatment options for opioid dependence currently available and to provide a critical discussion on the different treatment options based on these results. We performed a literature search using the PubMed databases and the reference lists of the identified articles. Data from research show that the three pharmacological options reviewed are effective treatments for opioid dependence with positive long term outcomes. However, each one has its specific target population and setting. While methadone and buprenorphine are first line options, heroin-assisted treatment is a second line option for those patients refractory to treatment with methadone with concomitant severe physical, mental, social and/or functional problems. Buprenorphine seems to be the best option for use in primary care offices. The field of opioid dependence treatment is poised to undergo a process of reinforcement and transformation. Further efforts from researchers, clinicians and authorities should be made to turn new pharmacological options into clinical reality and to overcome the structural and functional obstacles that maintenance programmes face in combatting opioid dependence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.