ArticleBMC genomics2012
Comparative genomics of bacteria in the genus Providencia isolated from wild Drosophila melanogaster.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- Pathogenic diversification of the gut commensalInfection and immunity · 2024Article
- Genomic revisitation and reclassification of the genusmSphere · 2024Article
- Presence of Functionally Active Cytolethal Distending Toxin Genes on a Conjugative Plasmid in a Clinical Isolate of Providencia rustigianii.Infection and immunity · 2023Article
- Pathogenicity of multiple Providencia species (Enterobacteriales: Morganellaceae) to the mass-reared Mexican fruit fly (Diptera: Tephritidae).Journal of insect science (Online) · 2023Article
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- Occurrence ofAntibiotics (Basel, Switzerland) · 2022Article
- Wild-type Caenorhabditis elegans isolates exhibit distinct gene expression profiles in response to microbial infection.BMC genomics · 2022Article
- Identification of an indole biodegradation gene cluster fromFrontiers in bioengineering and biotechnology · 2022Article
- Genomic analysis of the nomenclatural type strain of the nematode-associated entomopathogenic bacterium Providencia vermicola.BMC genomics · 2021Article
- Genome-Inferred Correspondence between Phylogeny and Metabolic Traits in the Wild Drosophila Gut Microbiome.Genome biology and evolution · 2021Article
- Genomes of Gut Bacteria frommSystems · 2021Article
- Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.BMC microbiology · 2020Article
- Isolation and genomic characterization of a pathogenic Providencia rettgeri strain G0519 in turtle Trachemys scripta.Antonie van Leeuwenhoek · 2020Article
- Performance and Application of 16S rRNA Gene Cycle Sequencing for Routine Identification of Bacteria in the Clinical Microbiology Laboratory.Clinical microbiology reviews · 2020Review
- Sequencing of five poultry strains elucidates phylogenetic relationships and divergence in virulence genes in Morganella morganii.BMC genomics · 2020Article
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2 authors.
Funding
Abstract
backgroundComparative genomics can be an initial step in finding the genetic basis for phenotypic differences among bacterial strains and species. Bacteria belonging to the genus Providencia have been isolated from numerous and varied environments. We sequenced, annotated and compared draft genomes of P. rettgeri, P. sneebia, P. alcalifaciens, and P. burhodogranariea. These bacterial species that were all originally isolated as infections of wild Drosophila melanogaster and have been previously shown to vary in virulence to experimentally infected flies.
resultsWe found that these Providencia species share a large core genome, but also possess distinct sets of genes that are unique to each isolate. We compared the genomes of these isolates to draft genomes of four Providencia isolated from the human gut and found that the core genome size does not substantially change upon inclusion of the human isolates. We found many adhesion related genes among those genes that were unique to each genome. We also found that each isolate has at least one type 3 secretion system (T3SS), a known virulence factor, though not all identified T3SS belong to the same family nor are they in syntenic genomic locations.
conclusionsThe Providencia species examined here are characterized by high degree of genomic similarity which will likely extend to other species and isolates within this genus. The presence of T3SS islands in all of the genomes reveal that their presence is not sufficient to indicate virulence towards D. melanogaster, since some of the T3SS-bearing isolates are known to cause little mortality. The variation in adhesion genes and the presence of T3SSs indicates that host cell adhesion is likely an important aspect of Providencia virulence.
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