ArticleXenotransplantation
Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species.
Article in Xenotransplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Orthotopic liver xenotransplantation from gene-modified pig to decedent human.Nature biomedical engineering · 2026Article
- Development of a pediatric pig model of extracorporeal cardiopulmonary resuscitation-induced acute kidney injury.Disease models & mechanisms · 2026Article
- New Findings on Pulsatile ECMO: Verification of the Potential to Improve Antithrombogenicity of a Membrane Oxygenator Using Pump-Generated Pulsatile Flow in an Innovative Animal Model.Artificial organs · 2025Article
- Revolutionizing medicine: Exploring the breakthroughs in liver xenotransplantation.Liver research (Beijing, China) · 2025Review
- The Future of Pig Liver Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation.Transplantation direct · 2024Article
- Immunohematological features of free-living Alouatta belzebul (Linnaeus, 1766) red-handed howler monkeys in the Eastern Amazon.Primates; journal of primatology · 2022Article
- What is the clinical relevance of deviant serum calcium and phosphate levels after pig-to-primate kidney xenotransplantation?Xenotransplantation · 2022Article
- Physiological aspects of pig kidney xenotransplantation and implications for management following transplant.Xenotransplantation · 2022Review
- Current Barriers to Clinical Liver Xenotransplantation.Frontiers in immunology · 2022Review
- Xenotransplantation: A New Era.Frontiers in immunology · 2022Review
- Biochemical and Hematologic Reference Intervals for Anesthetized, Female, Juvenile Yorkshire Swine.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Biomanufacturing of Axon-Based Tissue Engineered Nerve Grafts Using Porcine GalSafe Neurons.Tissue engineering. Part A · 2021Article
- Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?Biomolecules · 2020Review
- Complex formation of anti-VEGF-C with VEGF-C released during blood coagulation resulted in an artifact in its serum pharmacokinetics.Pharmacology research & perspectives · 2020Article
- Episodes of hypovolemia/dehydration in baboons with pig kidney transplants: A new syndrome of clinical importance?Xenotransplantation · 2019Article
- Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates.Comparative medicine · 2018Review
- Recent advances in lung transplantation.F1000Research · 2018Review
- Thrombelastography indicates limitations of animal models of trauma-induced coagulopathy.The Journal of surgical research · 2017Article
- HEREDITARY FACTOR VII DEFICIENCY IN THE ASIAN ELEPHANT (ELEPHAS MAXIMUS) CAUSED BY A F7 MISSENSE MUTATION.Journal of wildlife diseases · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe increasing availability of genetically engineered pigs is steadily improving the results of pig organ and cell transplantation in non-human primates (NHPs). Current techniques offer knockout of pig genes and/or knockin of human genes. Knowledge of normal values of hematologic, biochemical, coagulation, and other parameters in healthy genetically engineered pigs and NHPs is important, particularly following pig organ transplantation in NHPs. Furthermore, information on parameters in various NHP species may prove important in selecting the optimal NHP model for specific studies.
methodsWe have collected hematologic, biochemical, and coagulation data on 71 α1,3-galactosyltransferase gene-knockout (GTKO) pigs, 18 GTKO pigs additionally transgenic for human CD46 (GTKO.hCD46), four GTKO.hCD46 pigs additionally transgenic for human CD55 (GTKO.hCD46.hCD55), and two GTKO.hCD46 pigs additionally transgenic for human thrombomodulin (GTKO.hCD46.hTBM).
resultsWe report these data and compare them with similar data from wild-type pigs and the three major NHP species commonly used in biomedical research (baboons, cynomolgus, and rhesus monkeys) and humans, largely from previously published reports.
conclusionsGenetic modification of the pig (e.g., deletion of the Gal antigen and/or the addition of a human transgene) (i) does not result in abnormalities in hematologic, biochemical, or coagulation parameters that might impact animal welfare, (ii) seems not to alter metabolic function of vital organs, although this needs to be confirmed after their xenotransplantation, and (iii) possibly (though, by no means certainly) modifies the hematologic, biochemical, and coagulation parameters closer to human values. This study may provide a good reference for those working with genetically engineered pigs in xenotransplantation research and eventually in clinical xenotransplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.