SynthesisPLoS neglected tropical diseases2012
Bartonella bacilliformis: a systematic review of the literature to guide the research agenda for elimination.
Synthesis in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on antibiotic therapy of cutaneous bacillary angiomatosis not related to major immunocompromising conditions: from pathogenesis to treatment.BMC infectious diseases · 2024Pooled it
- Application of dimensionality reduction and clustering techniques for the analysis of Carrion's disease cases in the period 2000-2024.Frontiers in artificial intelligence · 2026Article
- Electrochemical Aptamer-Based Biosensor for Detecting Pap31, a Biomarker for Carrion's Disease.Sensors (Basel, Switzerland) · 2024Article
- Vector-Borne Zoonotic Lymphadenitis-The Causative Agents, Epidemiology, Diagnostic Approach, and Therapeutic Possibilities-An Overview.Life (Basel, Switzerland) · 2024Review
- In-silico identification of linear B-cell epitopes in specific proteins of Bartonella bacilliformis for the serological diagnosis of Carrion's disease.PLoS neglected tropical diseases · 2023Article
- Article
- Advancements in understanding the molecular and immune mechanisms ofFrontiers in microbiology · 2023Review
- Peru - Progress in health and sciences in 200 years of independence.Lancet regional health. Americas · 2022Review
- Phlebotomine sand flies (Diptera, Psychodidae) from Spain: an updated checklist and extended distributions.ZooKeys · 2022Article
- Immunogenic Peptides from Pap31 and SCS-α ofPathogens (Basel, Switzerland) · 2021Article
- Antibiotic Susceptibility of Bartonella Grown in Different Culture Conditions.Pathogens (Basel, Switzerland) · 2021Article
- Common Dermatologic Conditions in Returning Travelers.Current tropical medicine reports · 2021Article
- From Genome to Drugs: New Approaches in Antimicrobial Discovery.Frontiers in pharmacology · 2021Review
- Complete Genome Sequence of Bartonella bacilliformis Strain KC584 (ATCC 35686).Microbiology resource announcements · 2020Article
- Prioritisation of potential drug targets against Bartonella bacilliformis by an integrative in-silico approach.Memorias do Instituto Oswaldo Cruz · 2020Article
- Molecular detection and clinical characteristics of Bartonella bacilliformis, Leptospira spp., and Rickettsia spp. in the Southeastern Peruvian Amazon basin.BMC infectious diseases · 2018Article
- Molecular Detection ofThe American journal of tropical medicine and hygiene · 2018Article
- Molecular identification of Bartonella bacilliformis in ticks collected from two species of wild mammals in Madre de Dios: Peru.BMC research notes · 2018Article
- Carrion's Disease: the Sound of Silence.Clinical microbiology reviews · 2018Review
- Triatomines: Trypanosomatids, Bacteria, and Viruses Potential Vectors?Frontiers in cellular and infection microbiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarrion's disease affects small Andean communities in Peru, Colombia and Ecuador and is characterized by two distinct disease manifestations: an abrupt acute bacteraemic illness (Oroya fever) and an indolent cutaneous eruptive condition (verruga Peruana). Case fatality rates of untreated acute disease can exceed 80% during outbreaks. Despite being an ancient disease that has affected populations since pre-Inca times, research in this area has been limited and diagnostic and treatment guidelines are based on very low evidence reports. The apparently limited geographical distribution and ecology of Bartonella bacilliformis may present an opportunity for disease elimination if a clear understanding of the epidemiology and optimal case and outbreak management can be gained.
methodsAll available databases were searched for English and Spanish language articles on Carrion's disease. In addition, experts in the field were consulted for recent un-published work and conference papers. The highest level evidence studies in the fields of diagnostics, treatment, vector control and epidemiology were critically reviewed and allocated a level of evidence, using the Oxford Centre for Evidence-Based Medicine (CEBM) guidelines.
resultsA total of 44 studies were considered to be of sufficient quality to be included in the analysis. The majority of these were level 4 or 5 (low quality) evidence and based on small sample sizes. Few studies had been carried out in endemic areas.
conclusionsCurrent approaches to the diagnosis and management of Carrion's disease are based on small retrospective or observational studies and expert opinion. Few studies take a public health perspective or examine vector control and prevention. High quality studies performed in endemic areas are required to define optimal diagnostic and treatment strategies.
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