ArticlePloS one2012
A "spike-based" grammar underlies directional modification in network connectivity: effect on bursting activity and implications for bio-hybrids systems.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Spontaneous Dynamics Predict the Effects of Targeted Intervention in Hippocampal Neuronal Cultures.bioRxiv : the preprint server for biology · 2025Article
- Investigating the reliability of the evoked response in human iPSCs-derived neuronal networks coupled to micro-electrode arrays.APL bioengineering · 2023Article
- Plasticity and Adaptation in Neuromorphic Biohybrid Systems.iScience · 2020Review
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit.Frontiers in neural circuits · 2013Article
- Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.Frontiers in molecular neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Developed biological systems are endowed with the ability of interacting with the environment; they sense the external state and react to it by changing their own internal state. Many attempts have been made to build 'hybrids' with the ability of perceiving, modifying and reacting to external modifications. Investigation of the rules that govern network changes in a hybrid system may lead to finding effective methods for 'programming' the neural tissue toward a desired task. Here we show a new perspective in the use of cortical neuronal cultures from embryonic mouse as a working platform to study targeted synaptic modifications. Differently from the common timing-based methods applied in bio-hybrids robotics, here we evaluated the importance of endogenous spike timing in the information processing. We characterized the influence of a spike-patterned stimulus in determining changes in neuronal synchronization (connectivity strength and precision) of the evoked spiking and bursting activity in the network. We show that tailoring the stimulation pattern upon a neuronal spike timing induces the network to respond stronger and more precisely to the stimulation. Interestingly, the induced modifications are conveyed more consistently in the burst timing. This increase in strength and precision may be a key in the interaction of the network with the external world and may be used to induce directional changes in bio-hybrid systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.