ArticlePloS one2012
Natural variation in seed very long chain fatty acid content is controlled by a new isoform of KCS18 in Arabidopsis thaliana.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Innovative screening for mutants affected in seed oil/protein allocation identifies TRANSPARENT TESTA7 as a regulator of oil accumulation.The Plant journal : for cell and molecular biology · 2025Article
- ACT2.6: Global Gene Coexpression Network inGenes · 2025Article
- Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution.Plant communications · 2023Article
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- Natural Variation in 9-Cis-Epoxycartenoid Dioxygenase 3 and ABA Accumulation.Plant physiology · 2019Article
- Identification of Climate and Genetic Factors That Control Fat Content and Fatty Acid Composition ofFrontiers in plant science · 2019Article
- Natural variation in acyl editing is a determinant of seed storage oil composition.Scientific reports · 2018Article
- Seeds as oil factories.Plant reproduction · 2018Review
- Regulation of FATTY ACID ELONGATION1 expression and production in Brassica oleracea and Capsella rubella.Planta · 2017Article
- The Unique Role of the ECERIFERUM2-LIKE Clade of the BAHD Acyltransferase Superfamily in Cuticular Wax Metabolism.Plants (Basel, Switzerland) · 2017Review
- Analysis of Arabidopsis Accessions Hypersensitive to a Loss of Chloroplast Translation.Plant physiology · 2016Article
- Evolution of the KCS gene family in plants: the history of gene duplication, sub/neofunctionalization and redundancy.Molecular genetics and genomics : MGG · 2016Article
- Article
- Article
- Variation in sulfur and selenium accumulation is controlled by naturally occurring isoforms of the key sulfur assimilation enzyme ADENOSINE 5'-PHOSPHOSULFATE REDUCTASE2 across the Arabidopsis species range.Plant physiology · 2014Article
- Fatty acid composition and desaturase gene expression in flax (Linum usitatissimum L.).Journal of applied genetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oil from oleaginous seeds is mainly composed of triacylglycerols. Very long chain fatty acids (VLCFAs) are major constituents of triacylglycerols in many seed oils and represent valuable feedstock for industrial purposes. To identify genetic factors governing natural variability in VLCFA biosynthesis, a quantitative trait loci (QTL) analysis using a recombinant inbred line population derived from a cross between accessions Bay-0 and Shahdara was performed in Arabidopsis thaliana. Two fatty acid chain length ratio (CLR) QTL were identified, with one major locus, CLR.2, accounting for 77% of the observed phenotypic variation. A fine mapping and candidate gene approach showed that a key enzyme of the fatty acid elongation pathway, the β-ketoacyl-CoA synthase 18 (KCS18), was responsible for the CLR.2 QTL detected between Bay-0 and Shahdara. Association genetics and heterologous expression in yeast cells identified a single point mutation associated with an alteration of KCS18 activity, uncovering the molecular bases for the modulation of VLCFA content in these two natural populations of Arabidopsis. Identification of this kcs18 mutant with altered activity opens new perspectives for the modulation of oil composition in crop plants.
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