ArticlePloS one2012
Timeliness of clinic attendance is a good predictor of virological response and resistance to antiretroviral drugs in HIV-infected patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How does hard-to-reach status affect antiretroviral therapy adherence in the HIV-infected population? Results from a meta-analysis of observational studies.BMC public health · 2019Pooled it
- The effect of tuberculosis treatment on virologic and CD4+ cell count response to combination antiretroviral therapy: a systematic review.AIDS (London, England) · 2014Pooled it
- Trial
- Navigating the HIV continuum of care from treatment to retention strategies in Carnot, Central African Republic: a sequential explanatory mixed-methods study.BMJ global health · 2026Article
- Use of machine learning in predicting continuity of HIV treatment in selected Nigerian States.PLOS global public health · 2025Article
- Presence of Teen Clubs and its Association with Clinic Attendance among Adolescents Living with HIV in Tanzania: A Retrospective Cohort Study.The East African health research journal · 2023Article
- Historical visit attendance as predictor of treatment interruption in South African HIV patients: Extension of a validated machine learning model.PLOS global public health · 2023Article
- Preparing a financial incentive program to improve retention in HIV care and viral suppression for scale: using an implementation science framework to evaluate an mHealth system in Tanzania.Implementation science communications · 2021Article
- The association between severe menopausal symptoms and engagement with HIV care and treatment in women living with HIV.AIDS care · 2021Observational
- Associations of menopausal age with virological outcomes and engagement in care among women living with HIV in the UK.HIV research & clinical practice · 2020Article
- Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention.Current HIV/AIDS reports · 2020Review
- Expanded access to viral load testing and use of second line regimens in Haiti: time trends from 2010-2017.BMC infectious diseases · 2020Article
- [Determinants of non-compliance with antiretroviral therapy in adult patients in Kinshasa].The Pan African medical journal · 2020Article
- Factors associated with recent unsuppressed viral load in HIV-1-infected patients in care on first-line antiretroviral therapy in South Africa.International journal of STD & AIDS · 2018Observational
- Cultural adaptation of a cognitive-behavioural intervention to improve adherence to antiretroviral therapy among people living with HIV/AIDS in Zimbabwe: Nzira Itsva.Journal of health psychology · 2017Article
- The odyssey of linking to and staying in HIV care among male sex workers in Peru.Journal of HIV and AIDS · 2017Article
- Sociodemographic profile and predictors of outpatient clinic attendance among HIV-positive patients initiating antiretroviral therapy in Selangor, Malaysia.Patient preference and adherence · 2017Article
- Article
- Movement between facilities for HIV care among a mobile population in Kenya: transfer, loss to follow-up, and reengagement.AIDS care · 2016Article
- Depression Screening Using Daily Mental-Health Ratings from a Smartphone Application for Breast Cancer Patients.Journal of medical Internet research · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnsuring long-term adherence to therapy is essential for the success of HIV treatment. As access to viral load monitoring and genotyping is poor in resource-limited settings, a simple tool to monitor adherence is needed. We assessed the relationship between an indicator based on timeliness of clinic attendance and virological response and HIV drug resistance.
methodsData from 7 virological cross-sectional studies were pooled. An adherence indicator was calculated as the number of appointments attended with delay divided by the number of months between antiretroviral treatment (ART) initiation and date of virological testing and multiplying this by 100. Delays of 1 or more to 5 or more days were considered in turn. Multivariate random-intercept logistic regression was fitted to examine the effect on outcomes, separately for adults and children.
resultsA total of 3580 adults and 253 children were included. Adults were followed for a median of 26.0 months (IQR 12.8-45.0) and attended a median of 24 visits (IQR 13-34). The 1-day delay adherence indicator was strongly associated with viral load suppression (OR 0.96, 95% CI 0.95-0.97 per unit increase), virological failure (OR 1.05, 95% CI 1.03-1.06) and HIV drug resistance (OR 1.03, 95% CI 1.01-1.05) after adjusting for initial age and CD4 count, previous ART experience, type of regimen and Tuberculosis diagnosis at start of therapy. Similar results were observed in children.
conclusionAn adherence indicator based on timeliness of clinic attendance predicts strongly both virological response and drug resistance, and could help to timely identify non-adherent patients in settings where viral load monitoring is not available.
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