ArticlePloS one2012
Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Persimmon leaf extract in dyslipidemia: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Habitual consumption of long-chain n-3 PUFAs and fish attenuates genetically associated long-term weight gain.The American journal of clinical nutrition · 2019Trial
- Assessment of the Therapeutic Potential of Persimmon Leaf Extract on Prediabetic Subjects.Molecules and cells · 2017Trial
- Persimmon By-Products: Bioactive Phytochemicals, Sustainable Valorization and Potential Food and Health Applications.Nutrients · 2026Review
- Kaempferol-3-O-(2″-O-galloyl-β-D-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia-induced brain injury.Journal of natural medicines · 2024Article
- A Review: Pharmacological Effect of Natural Compounds inMolecules (Basel, Switzerland) · 2023Review
- Persimmon Leaves: Nutritional, Pharmaceutical, and Industrial Potential-A Review.Plants (Basel, Switzerland) · 2023Review
- Article
- Anti-Obesity and Anti-Hyperglycemic Effects ofInternational journal of molecular sciences · 2022Article
- A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups.Nutrients · 2021Review
- Anti-Diabetic Obesity Effects ofNutrients · 2020Article
- Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice.MedChemComm · 2018Article
- Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet.International journal of molecular medicine · 2017Article
- Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes glucagon-like peptide-1 secretion and expression in intestinal cells.British journal of pharmacology · 2017Article
- Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes.International journal of molecular medicine · 2017Article
- The Leaf ofPreventive nutrition and food science · 2016Article
- Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations.Journal of traditional and complementary medicine · 2016Article
- Beneficial effects of cocoa, coffee, green tea, and garcinia complex supplement on diet induced obesity in rats.BMC complementary and alternative medicine · 2016Article
- Article
- Effects of combined extract of cocoa, coffee, green tea and garcinia on lipid profiles, glycaemic markers and inflammatory responses in hamsters.BMC complementary and alternative medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persimmon Leaf (PL), commonly consumed as herbal tea and traditional medicines, contains a variety of compounds that exert antioxidant, α-amylase and α-glucosidase inhibitory activity. However, little is known about the in vivo effects and underlying mechanisms of PL on hyperglycemia, hyperlipidemia and hepatic steatosis in type 2 diabetes. Powered PL (5%, w/w) was supplemented with a normal diet to C57BL/KsJ-db/db mice for 5 weeks. PL decreased blood glucose, HOMA-IR, plasma triglyceride and total cholesterol levels, as well as liver weight, hepatic lipid droplets, triglycerides and cholesterol contents, while increasing plasma HDL-cholesterol and adiponectin levels. The anti-hyperglycemic effect was linked to decreased activity of gluconeogenic enzymes as well as increased glycogen content, glucokinase activity and its mRNA level in the liver. PL also led to a decrease in lipogenic transcriptional factor PPARγ as well as gene expression and activity of enzymes involved in lipogenesis, with a simultaneous increase in fecal lipids, which are seemingly attributable to the improved hyperlipidemia and hepatic steatosis and decreased hepatic fatty acid oxidation. Furthermore, PL ameliorated plasma and hepatic oxidative stress. Supplementation with PL may be an effective dietary strategy to improve type 2 diabetes accompanied by dyslipidemia and hepatic steatosis by partly modulating the activity or gene expression of enzymes related to antioxidant, glucose and lipid homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.