Evidence map›Paper›PMID 23145026›Full record

ArticlePloS one2012

A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response.

Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si-Yi Chen, Xue F Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Roles of A20 in autoimmune diseases.Immunologic research · 2016
    Review
  3. The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lifeng WangNorris Comprehensive Cancer Center, Department of Molecular Microbiology & Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Bangxing Hong
Xiaoxia Jiang
Lindsey Jones
Si-Yi Chen
Xue F Huang
University of Southern California · US

Funding

Overcoming Immune Suppression to Enhance Tumor Vaccine EfficacyR01CA090427 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, SI-YI · 2002 to 2013
$3.1M
Developing novel adjuvants for HIV vaccinationR01AI084811 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, SI-YI · 2009 to 2013
$2.2M
A Novel Oncolytic HSP Vaccine for Systemic Tumor TherapyR01CA100841 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HUANG, XUE F · 2006 to 2010
$1.1M
A UNIFYING ANTIGEN PRESENTATION STRATEGYR01AI048711 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CHEN, SI-YI · 2001 to 2003
$785k
Novel adjuvants of activating RIG-I and inhibiting immune inhibitors for HIV vaccR21AI087185 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HUANG, XUE F · 2010 to 2011
$444k
NCI NIH HHS R01 CA090427NCI NIH HHS R01 CA100841NCI NIH HHS R01CA100841NCI NIH HHS R01CA90427NIAID NIH HHS R01 AI048711NIAID NIH HHS R01 AI084811NIAID NIH HHS R01AI48711NIAID NIH HHS R21 AI087185NIAID NIH HHS R21AI087185PHS HHS R0148480
6 · The paper itself

Abstract

Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing. However, the critical issue is how the cytotoxic CD4(+) T cells are developed. During the course of our work that aims at promoting immunostimulation of APCs by inhibition of negative regulators, we found that A20-silenced Mф drastically induced granzyme B expression in CD4(+) T cells. As a consequence, the granzyme-highly expressing CD4(+) T cells exhibited a strong cytotoxic activity that restricted tumor development. We found that A20-silenced Mф activated cytotoxic CD4(+) T cells by MHC class-II restricted mechanism and the activation was largely dependent on enhanced production of IFN-γ.

Indexed as

AnimalsCD4-Positive T-LymphocytesCell Line, TumorCysteine EndopeptidasesCytotoxicity, ImmunologicDNA-Binding ProteinsGenes, MHC Class IIGranzymesInterferon-gammaIntracellular Signaling Peptides and ProteinsMacrophagesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicT-Lymphocytes, CytotoxicCysteine EndopeptidasesDNA-Binding ProteinsGranzymesInterferon-gammaIntracellular Signaling Peptides and ProteinsTnfaip3 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3Ubiquitin-Protein Ligases

Identifiers

PMID23145026
PMCPMC3492139
OpenAlexW2068442057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.