ArticlePloS one2012
Molecular evidence for the thriving of Campylobacter jejuni ST-4526 in Japan.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.The Journal of veterinary medical science · 2023Article
- Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.Microbiology spectrum · 2023Article
- Prevalence and antimicrobial resistance of Campylobacter and Salmonella in layer flocks in Honshu, Japan.The Journal of veterinary medical science · 2022Article
- Roles of Aerotolerance, Biofilm Formation, and Viable but Non-Culturable State in the Survival ofMicroorganisms · 2022Review
- Characterization of Campylobacter jejuni in large-billed crows (Corvus macrorhynchos) in Tochigi prefecture, Japan.The Journal of veterinary medical science · 2022Article
- Local accessory gene sharing among EgyptianMicrobial genomics · 2022Article
- The use of filamentous hemagglutinin adhesin to detect immune responses toFrontiers in veterinary science · 2022Article
- Quantitative detection and genetic characterization of thermotolerantFrontiers in microbiology · 2022Article
- Genome-wide insights into population structure and host specificity of Campylobacter jejuni.Scientific reports · 2021Article
- Population Biology and Comparative Genomics of Campylobacter Species.Current topics in microbiology and immunology · 2021Review
- Genomic epidemiology of Campylobacter jejuni associated with asymptomatic pediatric infection in the Peruvian Amazon.PLoS neglected tropical diseases · 2020Article
- Differential Distribution of theMicroorganisms · 2020Article
- Aerotolerance and multilocus sequence typing among Campylobacter jejuni strains isolated from humans, broiler chickens, and cattle in Miyazaki Prefecture, Japan.The Journal of veterinary medical science · 2019Article
- Article
- Characterization of Swedish Campylobacter coli clade 2 and clade 3 water isolates.MicrobiologyOpen · 2018Article
- Local genes for local bacteria: Evidence of allopatry in the genomes of transatlantic Campylobacter populations.Molecular ecology · 2017Article
- Article
- Comparative genomics and genome biology of invasive Campylobacter jejuni.Scientific reports · 2015Article
- Enhanced biofilm formation and multi-host transmission evolve from divergent genetic backgrounds in Campylobacter jejuni.Environmental microbiology · 2015Article
- Gene Loss and Lineage-Specific Restriction-Modification Systems Associated with Niche Differentiation in the Campylobacter jejuni Sequence Type 403 Clonal Complex.Applied and environmental microbiology · 2015Article
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Authors and funding
7 authors.
Funding
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Abstract
Campylobacter jejuni is a leading cause of human gastroenteritis worldwide. This study aimed at a better understanding of the genetic diversity of this pathogen disseminated in Japan. We performed multilocus sequence typing (MLST) of Campylobacter jejuni isolated from different sources (100 human, 61 poultry, and 51 cattle isolates) in Japan between 2005 and 2006. This approach identified 62 sequence types (STs) and 19 clonal complexes (CCs), including 11 novel STs. These 62 STs were phylogenetically divided into 6 clusters, partially exhibiting host association. We identified a novel ST (ST-4526) that has never been reported in other countries; a phylogenetic analysis showed that ST-4526 and related STs showed distant lineage from the founder ST, ST-21 within CC-21. Comparative genome analysis was performed to investigate which properties could be responsible for the successful dissemination of ST-4526 in Japan. Results revealed that three representative ST-4526 isolates contained a putative island comprising the region from Cj0737 to Cj0744, which differed between the ST-4526 isolates and the reference strain NCTC11168 (ST-43/CC-21). Amino acid sequence alignment analyses showed that two of three ST-4526 isolates expressed 693aa- filamentous hemagglutination domain protein (FHA), while most of other C. jejuni strains whose genome were sequenced exhibited its truncation. Correspondingly, host cell binding of FHA-positive C. jejuni was greater than that of FHA-truncated strains, and exogenous administration of rFHA protein reduced cell adhesion of FHA-positive bacteria. Biochemical assays showed that this putative protein exhibited a dose-dependent binding affinity to heparan sulfate, indicating its adhesin activity. Moreover, ST-4526 showed increased antibiotic-resistance (nalidixic acid and fluoroquinolones) and a reduced ability for DNA uptake. Taken together, our data suggested that these combined features contributed to the clonal thriving of ST-4526 in Japan.
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