ArticlePloS one2012
Bilayer elasticity at the nanoscale: the need for new terms.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Membrane-Mediated Interactions Between Protein Inclusions.Frontiers in molecular biosciences · 2021Review
- Directed Supramolecular Organization of N-BAR Proteins through Regulation of H0 Membrane Immersion Depth.Scientific reports · 2018Article
- The effect of gramicidin inclusions on the local order of membrane components.The European physical journal. E, Soft matter · 2018Article
- New Continuum Approaches for Determining Protein-Induced Membrane Deformations.Biophysical journal · 2017Article
- Continuum descriptions of membranes and their interaction with proteins: Towards chemically accurate models.Biochimica et biophysica acta · 2016Review
- The role of membrane-mediated interactions in the assembly and architecture of chemoreceptor lattices.PLoS computational biology · 2014Article
- Small scale membrane mechanics.Biomechanics and modeling in mechanobiology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuum elastic models that account for membrane thickness variations are especially useful in the description of nanoscale deformations due to the presence of membrane proteins with hydrophobic mismatch. We show that terms involving the gradient and the Laplacian of the area per lipid are significant and must be retained in the effective Hamiltonian of the membrane. We reanalyze recent numerical data, as well as experimental data on gramicidin channels, in light of our model. This analysis yields consistent results for the term stemming from the gradient of the area per molecule. The order of magnitude we find for the associated amplitude, namely 13-60 mN/m, is in good agreement with the 25 mN/m contribution of the interfacial tension between water and the hydrophobic part of the membrane. The presence of this term explains a systematic variation in previously published numerical data.
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