ArticlePloS one2012
Population genetic structure and origins of Native Hawaiians in the multiethnic cohort study.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Genetic Origins of the Kiritimati Population from Central-Eastern Micronesia.Genome biology and evolution · 2025Article
- Ethnic disparities in metabolic dysfunction-associated steatotic liver disease and clinical outcomes.Frontiers in endocrinology · 2025Article
- Native Hawaiian and Pacific Islander populations in genomic research.NPJ genomic medicine · 2024Review
- Exploring perspectives and insights of experienced voyagers on human health and Polynesian oceanic voyaging: A qualitative study.PloS one · 2024Article
- Tree-based QTL mapping with expected local genetic relatedness matrices.American journal of human genetics · 2023Article
- Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration.Frontiers in genetics · 2023Article
- Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases.International journal of molecular sciences · 2021Review
- The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians.PLoS genetics · 2021Article
- The Opportunities and Challenges of Integrating Population Histories Into Genetic Studies for Diverse Populations: A Motivating Example From Native Hawaiians.Frontiers in genetics · 2021Article
- Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians.Human molecular genetics · 2020Article
- Professional and Cultural Development of Medical Students Mentoring Adolescents in a Predominately Native Hawaiian Community.Hawai'i journal of health & social welfare · 2019Article
- Investigating the origins of eastern Polynesians using genome-wide data from the Leeward Society Isles.Scientific reports · 2018Article
- Desert Perennial Shrubs Shape the Microbial-Community Miscellany in Laimosphere and Phyllosphere Space.Microbial ecology · 2016Article
- Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort.European journal of clinical nutrition · 2016Article
- Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort.PloS one · 2015Article
- A Genomic Approach for Distinguishing between Recent and Ancient Admixture as Applied to Cattle.The Journal of heredityArticle
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
The population genetic structure of Native Hawaiians has yet to be comprehensively studied, and the ancestral origins of Polynesians remain in question. In this study, we utilized high-resolution genome-wide SNP data and mitochondrial genomes of 148 and 160 Native Hawaiians, respectively, to characterize their population structure of the nuclear and mitochondrial genomes, ancestral origins, and population expansion. Native Hawaiians, who self-reported full Native Hawaiian heritage, demonstrated 78% Native Hawaiian, 11.5% European, and 7.8% Asian ancestry with 99% belonging to the B4 mitochondrial haplogroup. The estimated proportions of Native Hawaiian ancestry for those who reported mixed ancestry (i.e. 75% and 50% Native Hawaiian heritage) were found to be consistent with their self-reported heritage. A significant proportion of Melanesian ancestry (mean = 32%) was estimated in 100% self-reported Native Hawaiians in an ADMIXTURE analysis of Asian, Melanesian, and Native Hawaiian populations of K = 2, where K denotes the number of ancestral populations. This notable proportion of Melanesian admixture supports the "Slow-Boat" model of migration of ancestral Polynesian populations from East Asia to the Pacific Islands. In addition, approximately 1,300 years ago a single, strong expansion of the Native Hawaiian population was estimated. By providing important insight into the underlying population structure of Native Hawaiians, this study lays the foundation for future genetic association studies of this U.S. minority population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.