Trial reportPloS one2012
High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Effect of Vitamin D Supplementation onFrontiers in endocrinology · 2022Pooled it
- Is vitamin D deficiency a major global public health problem?The Journal of steroid biochemistry and molecular biology · 2014Pooled it
- Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year.European journal of nutrition · 2018Trial
- Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Trial
- Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV.AIDS (London, England) · 2016Trial
- Circulating serum 25-hydroxyvitamin D levels and bone mineral density and osteoporotic vertebral fractures: A Mendelian randomization study.Journal of translational internal medicine · 2026Article
- Vitamin D and Uterine Fibroids: Insights into Pathophysiology and Therapeutic Potential.Endocrine reviews · 2026Review
- Dramatic Deterioration of Subclinical Hyperparathyroidism in Children and Adolescents During the Post-COVID-19 Period.Diseases (Basel, Switzerland) · 2025Article
- Lean Mass Index, Not Body Mass Index, is Essentially Associated with Arterial Stiffness in Chinese Adults: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Elevated TyG index is associated with increased risk of vitamin D deficiency among elderly patients with type 2 diabetes.Scientific reports · 2024Article
- Association of bone turnover markers and cognitive function in Chinese chronic schizophrenia patients with or without vitamin D insufficiency.BMC psychiatry · 2023Article
- Association between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus.Nutrients · 2023Article
- Free and bioavailable 25-hydroxyvitamin D thresholds for bone metabolism and their associations with metabolic syndrome in Chinese women of childbearing age.Frontiers in nutrition · 2023Article
- Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures.Bone & joint research · 2022Article
- Vitamin D deficiency and associated factors in south Korean childbearing women: a cross-sectional study.BMC nursing · 2021Article
- Article
- Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data.BMC musculoskeletal disorders · 2020Article
- Assessing vitamin D related genetic variants, status, and influence factors in pregnant women in Eastern and Central China.Food science & nutrition · 2020Article
- Associations of Serum Cathepsin K and Polymorphisms inFrontiers in endocrinology · 2020Article
- Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study involved 649 men and 1939 women aged 20-89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (<30 ng/mL) was 84% in males and 89% in females. The prevalence of vitamin D deficiency (<20 ng/mL) was 30% in males and 46% in females. With increasing serum 25(OH)D concentrations categorized as <10, 10-20, 20-30, and ≥30 ng/mL, the mean PTH and bone turnover markers levels gradually decreasd in both sexes (p<0.001). There was an inverse relationship between the serum 25(OH)D and PTH concentrations in both genders, but no threshold of 25(OH)D at which PTH levels plateaued was observed. There were modest but significantly inverse relationships between the levels of 25(OH)D and bone turnover markers, but no plateau was observed for serum 25(OH)D levels up to 40 ng/mL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.