ArticlePloS one2012
Relevance of brain lesion location to cognition in relapsing multiple sclerosis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Serum and cerebrospinal fluid biomarkers as predictors of cognitive impairment in multiple sclerosis: a systematic review of longitudinal studies.Journal of neurology · 2025Pooled it
- Pooled it
- Pharmacological treatment for memory disorder in multiple sclerosis.The Cochrane database of systematic reviews · 2013Pooled it
- Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis.Neurology · 2025Article
- Chronic Active Lesions and Larger Choroid Plexus Explain Cognition and Fatigue in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Prevalence of cognitive impairment (CI) in patients with multiple sclerosis (MS): A systematic review and meta-analysis.Caspian journal of internal medicine · 2024Review
- Cognitive function and brain magnetic resonance imaging profiles in neuromyelitis optica spectrum disorder and multiple sclerosis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Detecting isolated cognitive relapses in persons with MS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Multiple sclerosis lesions that impair memory map to a connected memory circuit.Journal of neurology · 2023Article
- Regional white matter and gray matter damage and cognitive performances in multiple sclerosis according to sex.Molecular psychiatry · 2023Article
- Review
- Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes.Neurology and therapy · 2022Review
- Microstructural White Matter Alterations in Cognitively Impaired Patients at Early Stages of Multiple Sclerosis.Clinical neuroradiology · 2021Article
- Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis.Brain sciences · 2021Review
- Tract-specific MRI measures explain learning and recall differences in multiple sclerosis.Brain communications · 2021Article
- The sequence of structural, functional and cognitive changes in multiple sclerosis.NeuroImage. Clinical · 2021Article
- Cerebellar volume loss in radiologically isolated syndrome.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Cognitive impairment in early MS: contribution of white matter lesions, deep grey matter atrophy, and cortical atrophy.Journal of neurology · 2020Article
- Mapping the Progressive Treatment-Related Reduction of Active MRI Lesions in Multiple Sclerosis.Frontiers in neurology · 2020Article
- The relationship between executive functions and fluid intelligence in multiple sclerosis.PloS one · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the relationship between cognition and brain white matter (WM) lesion distribution and frequency in patients with relapsing-remitting multiple sclerosis (RR MS).
methodsMRI-based T2 lesion probability map (LPM) was used to assess the relevance of brain lesion location for cognitive impairment in a group of 142 consecutive patients with RRMS. Significance of voxelwise analyses was p<0.05, cluster-corrected for multiple comparisons. The Rao Brief Repeatable Battery was administered at the time of brain MRI to categorize the MS population into cognitively preserved (CP) and cognitively impaired (CI).
resultsOut of 142 RRMS, 106 were classified as CP and 36 as CI. Although the CI group had greater WM lesion volume than the CP group (p = 0.001), T2 lesions tended to be less widespread across the WM. The peak of lesion frequency was almost twice higher in CI (61% in the forceps major) than in CP patients (37% in the posterior corona radiata). The voxelwise analysis confirmed that lesion frequency was higher in CI than in CP patients with significant bilateral clusters in the forceps major and in the splenium of the corpus callosum (p<0.05, corrected). Low scores of the Symbol Digit Modalities Test correlated with higher lesion frequency in these WM regions.
conclusionsOverall these results suggest that in MS patients, areas relevant for cognition lie mostly in the commissural fiber tracts. This supports the notion of a functional (multiple) disconnection between grey matter structures, secondary to damage located in specific WM areas, as one of the most important mechanisms leading to cognitive impairment in MS.
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